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Number of items at this level: 72.

Article in a Scientific Journal - peer-reviewed

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Basse, W. C., Gutowska, M. A., Findeisen, U., Stumpp, M., Dupont, S., Jackson, D. J., Himmerkus, N., Melzner, F. and Bleich, M. (2015) A sea urchin Na+K+2Cl− cotransporter is involved in the maintenance of calcification-relevant cytoplasmic cords in Strongylocentrotus droebachiensis larvae Comparative Biochemistry and Physiology A - Molecular and Integrative Physiology, 187 . pp. 184-192. DOI 10.1016/j.cbpa.2015.05.005.


Bleich, M. (2015) Challenge of paradigms in paracellular transport physiology Acta Physiologica, 213 . p. 6.


Bleich, M. (2009) Membrane Physiology -- Bridging the Gap between Medical Disciplines. New England Journal of Medicine, 360 (19). pp. 2012-2014.


Bleich, M. and Günzel, D. (2017) Physiology, pathophysiology, and clinical impact of claudins Pflügers Archiv - European Journal of Physiology, 469 (1). pp. 1-2. DOI 10.1007/s00424-016-1918-2.


Bleich, M., Schlatter, E. and Greger, R. (1990) The luminal K+ channel of the thick ascending limb of Henle's loop Pflügers Archiv European Journal of Physiology, 415 (4). pp. 449-460. DOI 10.1007/BF00373623.


Bleich, M., Shan, Q. and Himmerkus, N. (2012) Calcium regulation of tight junction permeability Annals of the New York Academy of Sciences, 1258 (1). pp. 93-99. DOI 10.1111/j.1749-6632.2012.06539.x.


Boldt, C., Roschel, T., Himmerkus, N., Plain, A., Bleich, M., Labes, R., Blum, M., Krause, H., Magheli, A., Giesecke, T., Mutig, K., Rothe, M., Weldon, S. M., Dragun, D., Schunck, W. H., Bachmann, S. and Paliege, A. (2016) Vasopressin lowers renal epoxyeicosatrienoic acid levels by activating soluble epoxide hydrolase American Journal of Physiology-Renal Physiology, 311 (6). F1198-F1210. DOI 10.1152/ajprenal.00062.2016.


Borschewski, A., Himmerkus, N., Boldt, C., Blankenstein, K. I., McCormick, J. A., Laze, R., Willnow, T. E., Jankowski, V., Plain, A., Bleich, M., Ellison, D. H., Bachmann, S. and Mutig, K. (2016) Calcineurin and Sorting-Related Receptor with A-Type Repeats Interact to Regulate the Renal Na+-K+-2Cl(-) Cotransporter Journal of the American Society of Nephrology, 27 (1). pp. 107-119. DOI 10.1681/ASN.2014070728.


Breiderhoff, T., Himmerkus, N., Mutig, K., Mueller, D., Bleich, M. and Willnow, T. (2014) Pathophysiology of claudin 10 deficiency in mice Acta Physiologica, 210 . p. 44.


Breiderhoff, T., Himmerkus, N., Stuiver, M., Mutig, K., Will, C., Meij, I. C., Bachmann, S., Bleich, M., Willnow, T. E. and Muller, D. (2012) Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis Proceedings of the National Academy of Sciences, 109 (35). pp. 14241-14246. DOI 10.1073/pnas.1203834109.


Debert, D., Klootwijk, E. D., Himmerkus, N., Kleta, R. and Bleich, M. (2015) ATP induced intracellular calcium signaling in Fam20a deficient proximal tubular cells Acta Physiologica, 213 . p. 151.


Gong, Y., Himmerkus, N., Plain, A., Bleich, M. and Hou, J. (2015) Epigenetic Regulation of MicroRNAs Controlling CLDN14 Expression as a Mechanism for Renal Calcium Handling Journal of the American Society of Nephrology, 26 (3). pp. 663-676.


Gong, Y., Himmerkus, N., Sunq, A., Milatz, S., Merkel, C., Bleich, M. and Hou, J. (2017) ILDR1 is important for paracellular water transport and urine concentration mechanism Proceedings of the National Academy of Sciences, 114 (20). pp. 5271-5276. DOI 10.1073/pnas.1701006114.


Gong, Y., Renigunta, V., Himmerkus, N., Zhang, J., Renigunta, A., Bleich, M. and Hou, J. (2012) Claudin-14 regulates renal Ca++transport in response to CaSR signalling via a novel microRNA pathway The EMBO Journal, 31 (8). pp. 1999-2012. DOI 10.1038/emboj.2012.49.


Guenzel, D. and Bleich, M. (2014) Introduction to structure and physiology of tight junctions Acta Physiologica, 210 . p. 44.


Heinekamp, L., Himmerkus, N., Lucius, R., Boretius, S., Kleta, R. and Bleich, M. (2016) Phenotyping of Fam20a-knock out-mice Acta Physiologica, 216 .


Himmerkus, N., Bleich, M. and Steels, P. (2014) Recovery of electrogenic transport and intracellular pH in isolated perfused thick ascending limb after metabolic ischemia Acta Physiologica, 210 . p. 188.


Himmerkus, N., Linkermann, A., Krautwald, S., Kunzendorf, U. and Bleich, M. (2016) Erastin induced ferroptosis in isolated perfused proximal tubules Acta Physiologica, 216 .


Himmerkus, N., Plain, A., Marques, R. D., Sonntag, S. R., Paliege, A., Leipziger, J. and Bleich, M. (2017) AVP dynamically increases paracellular Na+ permeability and transcellular NaCl transport in the medullary thick ascending limb of Henle’s loop Pflügers Archiv - European Journal of Physiology, 469 (1). pp. 149-158. DOI 10.1007/s00424-016-1915-5.


Himmerkus, N., Plain, A., Wulfmeyer, V. C., Klietz, A., Hou, J., Bleich, M. and Milatz, S. (2016) Electrophysiological properties and effects of excess dietary calcium intake along the cortico-medullary axis of the thick ascending limb of the loop of Henle Acta Physiologica, 216 .


Himmerkus, N., Shan, Q. X., Goerke, B., Hou, J. H., Goodenough, D. A. and Bleich, M. (2008) Salt and acid-base metabolism in claudin-16 knockdown mice: impact for the pathophysiology of FHHNC patients American Journal of Physiology: Renal Physiology, 295 (6). F1641-F1647.


Himmerkus, N., Sievers, B. and Bleich, M. (2012) Carbamazepine affects water and electrolyte homoeostasis in rat--similarities and differences to vasopressin antagonism Nephrology Dialysis Transplantation, 27 (10). pp. 3790-3798. DOI 10.1093/ndt/gfs107.

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Holtmann, W., Stumpp, M., Gutowska, M., Syre, S., Himmerkus, N., Melzner, F. and Bleich, M. (2013) Maintenance of coelomic fluid pH in sea urchins exposed to elevated CO2: the role of body cavity epithelia and stereom dissolution Marine Biology, 160 (10). pp. 2631-2645. DOI 10.1007/s00227-013-2257-x.

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Hu, M. Y. A., Tseng, Y. C., Stumpp, M., Gutowska, M., Kiko, R., Lucassen, M. and Melzner, F. (2011) Elevated seawater pCO2 differentially affects branchial acid-base transporters over the course of development in the cephalopod Sepia officinalis American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 300 . pp. 1100-1114. DOI 10.1152/ajpregu.00653.2010.

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Hu, M. Y. A., Tseng, Y. C., Su, Y. H., Lein, E., Lee, H. G., Lee, J. R., Dupont, S. and Stumpp, M. (2017) Variability in larval gut pH regulation defines sensitivity to ocean acidification in six species of the Ambulacraria superphylum Proceedings of the Royal Society B-Biological Sciences, 284 (1864). Art. Nr.20171066. DOI 10.1098/rspb.2017.1066.


Hu, M., Tseng, Y. C., Lein, E., Bleich, M. and Stumpp, M. (2016) Digestion physiology predicts sensitivity to CO2-driven sea-water acidification in non-calcifying marine larvae Acta Physiologica, 216 .


Jentsch, T. J., Schroeder, B. C., Waldegger, S., Fehr, S., Bleich, M., Warth, R. and Greger, R. (2000) A constitutively open potassium channel formed by KCNQ1 and KCNE3 Nature, 403 (6766). pp. 196-199. DOI 10.1038/35003200.


Klietz, A., Himmerkus, N., Gruessel, S., Wulfmeyer, V. and Bleich, M. (2014) Paracellular pathway properties of primary cultured in comparison to freshly isolated proximal tubules Acta Physiologica, 210 . p. 188.


Knopfel, T., Himmerkus, N., Gunzel, D., Bleich, M., Hernando, N. and Wagner, C. A. (2016) Paracellular phosphate permeability in the intestine Acta Physiologica, 216 .


Larsen, C. K., Jensen, I. S., Sorensen, M. V., de Bruijn, P. I., Bleich, M., Praetorius, H. A. and Leipziger, J. (2016) Hyperaldosteronism after decreased renal K+ excretion in KCNMB2 knockout mice American Journal of Physiology-Renal Physiology, 310 (10). F1035-F1046. DOI 10.1152/ajprenal.00010.2016.


Larsen, C. K., Jensen, I. S., Sorensen, M. V., de Bruijn, P. I., Bleich, M., Praetorius, H. A. and Leipziger, J. (2016) Hyperaldosteronism after decreased renal K+excretion in KCNMB2 knockout mice American Journal of Physiology - Renal Physiology, 310 (10). F1035-F1046. DOI 10.1152/ajprenal.00010.2016.


Lazelle, R. A., McCully, B. H., Terker, A. S., Himmerkus, N., Blankenstein, K. I., Mutig, K., Bleich, M., Bachmann, S., Yang, C. L. and Ellison, D. H. (2016) Renal Deletion of 12 kDa FK506-Binding Protein Attenuates Tacrolimus-Induced Hypertension Journal of the American Society of Nephrology, 27 (5). pp. 1456-1464. DOI 10.1681/ASN.2015040466.


Linkermann, A., Himmerkus, N., Rolver, L., Keyser, K. A., Steen, P., Brasen, J. H., Bleich, M., Kunzendorf, U. and Krautwald, S. (2011) Renal tubular Fas ligand mediates fratricide in cisplatin-induced acute kidney failure Kidney International, 79 (2). pp. 169-178. DOI 10.1038/ki.2010.317.


Linkermann, A., Skouta, R., Himmerkus, N., Mulay, S. R., Dewitz, C., De Zen, F., Prokai, A., Zuchtriegel, G., Krombach, F., Welz, P. S., Weinlich, R., Vanden Berghe, T., Vandenabeele, P., Pasparakis, M., Bleich, M., Weinberg, J. M., Reichel, C. A., Braesen, J. H., Kunzendorf, U., Anders, H. J., Stockwell, B. R., Green, D. R. and Krautwald, S. (2014) Synchronized renal tubular cell death involves ferroptosis Proceedings of the National Academy of Sciences of the United States of America, 111 (47). pp. 16836-16841.


Marques, R. D., de Bruijn, P. I. A., Sorensen, M. V., Bleich, M., Praetorius, H. A. and Leipziger, J. (2012) Basolateral P2X receptors mediate inhibition of NaCl transport in mouse medullary thick ascending limb (mTAL) AJP: Renal Physiology, 302 (4). F487-F494. DOI 10.1152/ajprenal.00570.2011.


McCormick, J. A., Yang, C. L., Zhang, C., Davidge, B., Blankenstein, K. I., Terker, A. S., Yarbrough, B., Meermeier, N. P., Park, H. J., McCully, B., West, M., Borschewski, A., Himmerkus, N., Bleich, M., Bachmann, S., Mutig, K., Argaiz, E. R., Gamba, G., Singer, J. D. and Ellison, D. H. (2014) Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3 Journal of Clinical Investigation, 124 (11). pp. 4723-4736.

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Melzner, F., Gutowska, M. A., Langenbuch, M., Dupont, S., Lucassen, M., Thorndyke, M. C., Bleich, M. and Pörtner, H. O. (2009) Physiological basis for high CO2 tolerance in marine ectothermic animals: pre-adaptation through lifestyle and ontogeny? Biogeosciences (BG), 6 . pp. 2313-2331. DOI 10.5194/bg-6-2313-2009.


Milatz, S., Himmerkus, N., Wulfmeyer, V. C., Drewell, H., Mutig, K., Breiderhoff, T., Fromm, M., Hou, J., Bleich, M. and Gunzel, D. (2016) Distribution, interaction and function of claudins in the thick ascending limb of Henle's loop Acta Physiologica, 216 .


Milatz, S., Himmerkus, N., Wulfmeyer, V. C., Drewell, H., Mutig, K., Hou, J., Breiderhoff, T., Müller, D., Fromm, M., Bleich, M. and Günzel, D. (2016) Mosaic expression of claudins in thick ascending limbs of Henle results in spatial separation of paracellular Na+and Mg2+transport Proceedings of the National Academy of Sciences, 114 (2). E219-E227. DOI 10.1073/pnas.1611684114.


Penton, D., Czogalla, J., Wengi, A., Himmerkus, N., Loffing-Cueni, D., Carrel, M., Rajaram, R. D., Staub, O., Bleich, M., Schweda, F. and Loffing, J. (2016) Extracellular K+ rapidly controls NaCl cotransporter phosphorylation in the native distal convoluted tubule by Cl--dependent and independent mechanisms Journal of Physiology-London, 594 (21). pp. 6319-6331. DOI 10.1113/JP272504.


Penton, D., Czogalla, J., Wengi, A., Himmerkus, N., Loffing-Cueni, D., Carrel, M., Rajaram, R. D., Staub, O., Bleich, M., Schweda, F. and Loffing, J. (2016) Extracellular K+rapidly controls NaCl cotransporter phosphorylation in the native distal convoluted tubule by Cl−-dependent and independent mechanisms The Journal of Physiology, 594 (21). pp. 6319-6331. DOI 10.1113/JP272504.


Plain, A., Himmerkus, N. and Bleich, M. (2014) The influence of stimulation of the cAMP pathway on paracellular permeability in the thick ascending limb (TAL) Acta Physiologica, 210 . p. 190.


Plain, A., Wulfmeyer, V. C., Milatz, S., Klietz, A., Hou, J. H., Bleich, M. and Himmerkus, N. (2016) Corticomedullary difference in the effects of dietary Ca2+ on tight junction properties in thick ascending limbs of Henle's loop Pflugers Archiv-European Journal of Physiology, 468 (2). pp. 293-303. DOI 10.1007/s00424-015-1748-7.


Plain, A., Wulfmeyer, V. C., Milatz, S., Klietz, A., Hou, J., Bleich, M. and Himmerkus, N. (2016) Corticomedullary difference in the effects of dietary Ca2+ on tight junction properties in thick ascending limbs of Henle’s loop Pflügers Archiv - European Journal of Physiology, 468 (2). pp. 293-303. DOI 10.1007/s00424-015-1748-7.


Reuter, S., Velic, A., Edemir, B., Schroter, R., Pavenstadt, H., Gabriels, G., Bleich, M. and Schlatter, E. (2008) Protective role of NHE-3 inhibition in rat renal transplantation undergoing acute rejection Pflügers Archiv - European Journal of Physiology, 456 (6). pp. 1075-1084.


Saritas, T., Borschewski, A., McCormick, J. A., Paliege, A., Dathe, C., Uchida, S., Terker, A., Himmerkus, N., Bleich, M., Demaretz, S., Laghmani, K., Delpire, E., Ellison, D. H., Bachmann, S. and Mutig, K. (2013) SPAK Differentially Mediates Vasopressin Effects on Sodium Cotransporters Journal of the American Society of Nephrology, 24 (3). pp. 407-418.


Saritas, T., Borschewski, A., McCormick, J., Paliege, A., Dathe, C., Uchida, S., Bleich, M., Himmerkus, N., Delpire, E., Ellison, D., Bachmann, S. and Mutig, K. (2013) STE20-LIKE KINASE SPAK DIFFERENTIALLY REGULATES Na-( K)-Cl COTRANSPORTERS ALONG THE DISTAL NEPHRON UNDER THE ENDOCRINE CONTROL OF AVP Nephrology Dialysis Transplantation, 28 . p. 69.


Schröder, J., Lüllmann-Rauch, R., Himmerkus, N., Pleines, I., Nieswandt, B., Orinska, Z., Koch-Nolte, F., Schröder, B., Bleich, M. and Saftig, P. (2009) Deficiency of the Tetraspanin CD63 Associated with Kidney Pathology but Normal Lysosomal Function Molecular and Cellular Biology, 29 (4). pp. 1083-1094. DOI 10.1128/MCB.01163-08.


Shan, Q. X., Himmerkus, N., Hou, J. H., Goodenough, D. A. and Bleich, M. (2009) Insights into Driving Forces and Paracellular Permeability from Claudin-16 Knockdown Mouse Annals of the New York Academy of Sciences, 1165 . pp. 148-151. DOI 10.1111/j.1749-6632.2009.04041.x.


Strobel, A., Hu, M. Y. A., Gutowska, M., Lieb, B., Lucassen, M., Melzner, F., Pörtner, H. O. and Mark, F. C. (2012) Influence of Temperature, Hypercapnia, and Development on the Relative Expression of Different Hemocyanin Isoforms in the Common CuttlefishSepia officinalis Journal of Experimental Zoology Part A: Ecological Genetics and Physiology, 317 (8). pp. 511-523. DOI 10.1002/jez.1743.

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Stumpp, M., Hu, M. Y. A., Casties, I., Saborowski, R., Bleich, M., Melzner, F. and Dupont, S. (2013) Digestion in sea urchin larvae impaired under ocean acidification Nature Climate Change, 3 (12). pp. 1044-1049. DOI 10.1038/nclimate2028.

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Stumpp, M., Hu, M. Y. A., Melzner, F., Gutowska, M., Dorey, N., Himmerkus, N., Holtmann, W. C., Dupont, S. T., Thorndyke, M. C. and Bleich, M. (2012) Acidified seawater impacts sea urchin larvae pH regulatory systems relevant for calcification Proceedings of the National Academy of Sciences of the United States of America, 109 (44). pp. 18192-18197. DOI 10.1073/pnas.1209174109.

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Suffrian, K., Schulz, K. G., Gutowska, M., Riebesell, U. and Bleich, M. (2011) Cellular pH measurements in Emiliania huxleyi reveal pronounced membrane proton permeability New Phytologist, 190 (3). pp. 595-608. DOI 10.1111/j.1469-8137.2010.03633.x.

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Taubner, I., Böhm, F., Eisenhauer, A., Tambutté, E., Tambutté, S., Moldzio, S. and Bleich, M. (2017) An improved approach investigating epithelial ion transport in scleractinian corals Limnology and Oceanography: Methods, 15 (9). pp. 753-765. DOI 10.1002/lom3.10194.

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Thomsen, J., Gutowska, M., Saphörster, J., Heinemann, A., Trübenbach, K., Fietzke, J., Hiebenthal, C., Eisenhauer, A., Körtzinger, A., Wahl, M. and Melzner, F. (2010) Calcifying invertebrates succeed in a naturally CO2 enriched coastal habitat but are threatened by high levels of future acidification Biogeosciences (BG), 7 (11). pp. 3879-3891. DOI 10.5194/bg-7-3879-2010.


Thomsen, J., Himmerkus, N., Bleich, M. and Tresguerres, M. (2016) Sites and principles of ammonia excretion in marine mussels Acta Physiologica, 216 .


Thomsen, J., Himmerkus, N., Holland, N., Sartoris, F. J., Bleich, M. and Tresguerres, M. (2016) Ammonia excretion in mytilid mussels is facilitated by ciliary beating Journal of Experimental Biology, 219 (15). pp. 2300-2310. DOI 10.1242/jeb.139550 .

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Thomsen, J., Himmerkus, N., Holland, N., Sartoris, F. J., Bleich, M. and Tresguerres, M. (2016) Ammonia excretion in mytilid mussels is facilitated by ciliary beating The Journal of Experimental Biology, 219 (15). pp. 2300-2310. DOI 10.1242/jeb.139550.


de Bruijn, P. I. A., Bleich, M., Praetorius, H. A. and Leipziger, J. (2015) P2X receptors trigger intracellular alkalization in isolated perfused mouse medullary thick ascending limb Acta Physiologica, 213 (1). pp. 277-284.


de Bruijn, P., Larsen, C., Himmerkus, N., Frische, S., Bleich, M., Praetorius, H. and Leipziger, J. (2015) Furosemide-induced urinary acidification is caused by pronounced H+ secretion in the thick ascending limb Acta Physiologica, 213 . p. 60.

Article in a Scientific Journal - without review


Himmerkus, N., Borschewski, A., Plain, A., Bachmann, S., Mutig, K. and Bleich, M. (2015) Modulation of NKCC2 function by phosphorylation Acta Physiologica, 213 . pp. 60-61.


Plain, A., Marquez, R. D., Himmerkus, N., Leipziger, J. and Bleich, M. (2015) AVP-mediated regulation of the paracellular permeability in the thick ascending limb (TAL) Acta Physiologica, 213 . p. 196.


Pohl, M., Shan, Q., Petsch, T., Styp-Rekowska, B., Matthey, P., Bleich, M., Bachmann, S. and Theilig, F. (2015) Short-Term Functional Adaptation of Aquaporin-1 Surface Expression in the Proximal Tubule, a Component of Glomerulotubular Balance Journal of the American Society of Nephrology, 26 (6). pp. 1269-1278.


Sonntag, S. R., Himmerkus, N., Krause, A. and Bleich, M. (2015) Influence of different diuretic states on the paracellular pathway of inner medullary collecting ducts and thin limbs Acta Physiologica, 213 . p. 197.

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Taubner, I., Tambutte, E., Tambutte, S., Eisenhauer, A., Böhm, F. and Bleich, M. (2016) Assay development for electrophysiological studies in the hermatypic coral Stylophora pistillata Acta Physiologica, 216 (Suppl. 707, SI Meeting Abstract: P21-12 ).

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Thomsen, J., Ramesh, K., Sanders, T., Bleich, M. and Melzner, F. (2017) Calcification in a marginal sea - influence of seawater [Ca2+] and carbonate chemistry on bivalve shell formation Biogeosciences Discussions, 342 . pp. 1-24. DOI 10.5194/bg-2017-342.

Conference poster


Form, A., Holtmann, W., Piepenburg, D., Bleich, M. and Riebesell, U. (2011) Acclimation effects of ocean acidification in the cold-water coral Lophelia pertusa and first investigations of single-channel activities [Poster] In: BIOACID Annual Meeting 2011, 26.-30.09.2011, Bremen, Germany.

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Taubner, I., Tambutté, E., Tambutté, S., Eisenhauer, A. and Bleich, M. (2010) Influence of pH, light and salinity on element transport in calcifying tropical corals (BIOACID subproject 3.3.2) [Poster] In: Joint EPOCA, BIOACID and UKOARP Meeting, 27.09.-30.09.2010, Bremerhaven.


Yan, J. J., Stumpp, M., Bleich, M., Su, Y. H., Arnone, M. I. and Hu, M. Y. (2016) Regulatory Factors Controlling the functional development of the digestive system in a basal deuterostome [Poster] In: Deutsche Zoologen Tagung, 14. - 17. 9. 2016, Kiel, Germany.

Thesis - not published by a publisher

Brüggemann, K. (2013) The effects of elevated temperature on development and gas exchange in embryonic sharks (Master thesis), Christian-Albrechts-Universität Kiel, Kiel, Germany, 33 pp


Holtmann, W. (2008) Electrophysical studies of the cold-water coral Lophelia pertusa: dissection of the epithelium and measurements of single-channel currents (Diploma thesis), Christian-Albrechts-Universität Kiel, Kiel, Germany, 82 pp

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Hu, M. Y. A. (2011) Mechanistic studies on the physiology of CO2 tolerance in cephalopods (Doctoral thesis/PhD), Christian-Albrechts-Universität, Kiel, Germany, 201 pp

This list was generated on Thu Nov 23 14:44:40 2017 CET.