Piceamycin and its N-acetylcysteine adduct is produced by Streptomyces sp GB 4-2

Schulz, D., Nachtigall, J., Riedlinger, J., Schneider, K., Poralla, K., Imhoff, Johannes F., Beil, W., Nicholson, G., Fiedler, H. P. and Sussmuth, R. D. (2009) Piceamycin and its N-acetylcysteine adduct is produced by Streptomyces sp GB 4-2 Journal of Antibiotics, 62 (9). pp. 513-518. DOI 10.1038/ja.2009.64.

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Abstract

Piceamycin, a new macrolactam polyketide antibiotic, was detected by HPLC-diode array screening in extracts of Streptomyces sp. GB 4-2, which was isolated from the mycorrhizosphere of Norway spruce. The structure of piceamycin was determined by mass spectrometry and NMR experiments. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and protein tyrosine phosphatase 1B. The Journal of Antibiotics (2009) 62, 513-518; doi:10.1038/ja.2009.64; published online 17 July 2009

Document Type: Article
Keywords: macrolactam antibioticpolyketide protein tyrosine phosphatase 1b inhibitor streptomyces structural elucidation structure elucidation metabolite auxofuran ach-505 growth
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
DOI etc.: 10.1038/ja.2009.64
ISSN: 0021-8820
Projects: Future Ocean
Date Deposited: 11 Feb 2011 12:14
Last Modified: 13 Jun 2017 09:48
URI: http://eprints.uni-kiel.de/id/eprint/9714

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