Hydra and the evolution of stem cells

Bosch, T. C. G. (2009) Hydra and the evolution of stem cells Bioessays, 31 (4). 478-486.

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Hydra are remarkable because they are immortal. Much of immortality can be ascribed to the asexual mode of reproduction by budding, which requires a tissue consisting of stem cells with continuous self-renewal capacity. Emerging novel technologies and the availability of genomic resources enable for the first time to analyse these cells in vivo. Stem cell differentiation in Hydra is governed through the coordinated actions of conserved signaling pathways. Studies of stem cells in Hydra, therefore, promise critical insights of general relevance into stem cell biology including cellular senescence, lineage programming and reprogramming, the role of extrinsic signals in fate determination and tissue homeostasis, and the evolutionary origin of these cells. With these new facts as a backdrop, this review traces the history of studying stem cells in Hydra and offers a view of what the future may hold.

Document Type: Article
Research affiliation: Kiel University
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
ISSN: 0265-9247
Projects: Future Ocean
Date Deposited: 11 Feb 2011 12:15
Last Modified: 24 Oct 2017 12:14
URI: http://eprints.uni-kiel.de/id/eprint/9307

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