Effect of a short- and long-term treatment with Ginkgo biloba extract on Amyloid Precursor Protein Levels in a transgenic mouse model relevant to Alzheimer's disease

Augustin, S., Rimbach, Gerald, Augustin, K., Schliebs, R., Wolffram, S. and Cermak, R. (2009) Effect of a short- and long-term treatment with Ginkgo biloba extract on Amyloid Precursor Protein Levels in a transgenic mouse model relevant to Alzheimer's disease Archives of Biochemistry and Biophysics, 481 (2). pp. 177-182.

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Abstract

Several Clinical trials have reported beneficial effects of the Ginkgo biloba extract EGb761 in the prevention and therapy of cognitive disorders including Alzheimer's disease (AD). The aim of the present long-term feeding trial Was to Study the impact of dietary EGb761 on Amyloid precursor protein (APP) metabolism in mice transgenic for human APP (Tg2576). Tg2576 mice were fed diets with and Without EGb761 (300 mg/kg diet) for I and 16 months, respectively. Long-term treatment (16 months) with EGb761 significantly lowered human APP protein levels by similar to 50% as compared to controls in the cortex but not in the hippocampus. However, APP levels were not affected by EGb761 in young mice. Current data indicate that APP seems to be all important molecular target of EGb761 ill relation to the duration of the Ginkgo biloba treatment and/or the age of the animals. Potential neuroprotective properties of EGb761 may be, at least partly, related to its APP lowering activity. (C) 2008 Published by Elsevier Inc.

Document Type: Article
Keywords: ginkgo bilobaalzheimer's disease tg2576 amyloid precursor protein alpha-secretase promoter region mice egb-761 metabolism identification expression prevention dementia efficacy increase
Research affiliation: Kiel University
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
ISSN: 0003-9861
Projects: Future Ocean
Date Deposited: 11 Feb 2011 12:13
Last Modified: 26 May 2016 12:30
URI: http://eprints.uni-kiel.de/id/eprint/9277

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