Identification of a kazal-type serine protease inhibitor with potent anti-staphylococcal activity as part of hydra's innate immune system

Augustin, R., Siebert, S. and Bosch, T. C. G. (2009) Identification of a kazal-type serine protease inhibitor with potent anti-staphylococcal activity as part of hydra's innate immune system Developmental and Comparative Immunology, 33 (7). pp. 830-837. DOI 10.1016/j.dci.2009.01.009.

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Abstract

In the absence of migratory phagocytic cells the basal metazoan Hydra has developed a very effective immune system. Previous work has shown that epithelial cells, both in the ectoderm and endoderm, recognize PAMPs by TLR and produce a number of antimicrobial peptides. In this study we demonstrate that not only epithelial cells but also gland cells are critically involved in Hydra's innate host defense by producing a kazal-type serine protease inhibitor, kazal2, that has potent in vitro bactericidal activity against Staphylococcus aureus. The discovery of an antimicrobial serine protease inhibitor in Hydra may shed new light on the mechanisms of host defense early in metazoan evolution, and promises to open new avenues for the development of potent anti-staphylococcal compounds.

Document Type: Article
Keywords: Innate immunity; Epithelial defense; Secretory gland cells; Kazal-type serine protease inhibitor; Hydra; Staphylococcus aureus
Research affiliation: Kiel University
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
DOI etc.: 10.1016/j.dci.2009.01.009
ISSN: 0145-305X
Projects: Future Ocean
Date Deposited: 11 Feb 2011 12:16
Last Modified: 02 Nov 2016 13:51
URI: http://eprints.uni-kiel.de/id/eprint/9276

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