Bivalve models of aging and the determination of molluscan lifespans

Abele, D., Brey, T. and Philipp, Eva (2009) Bivalve models of aging and the determination of molluscan lifespans Experimental Gerontology, 44 (5). pp. 307-315.

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Bivalves are newly discovered models of natural aging. This invertebrate group includes species with the longest metazoan lifespan approaching 400 y, as well as species of swimming and sessile lifestyles that live just for 1 y. Bivalves from natural populations can be aged by shell growth bands formed at regular intervals of time. This enables the study of abiotic and biotic environment factors (temperature, salinity, predator and physical disturbance) on senescence and fitness in natural populations, and distinguishes the impact of extrinsic effectors from intrinsic (genetic) determinants of animal aging. Extreme longevity of some bivalve models may help to analyze general metabolic strategies thought to be life prolonging, like the transient depression of metabolism, which forms part of natural behaviour in these species. Thus, seasonal food shortage experienced by benthic filter feeding bivalves in polar and temperate seas may mimic caloric restriction in vertebrates. Incidence of malignant neoplasms in bivalves needs to be investigated, to determine the implication of late acting mutations for bivalve longevity. Finally, bivalves are applicable models for testing the implication of heterozygosity of multiple genes for physiological tolerance, adaptability (heterozygote superiority), and life expectancy. (C) 2009 Elsevier Inc. All rights reserved.

Document Type: Article
Keywords: bivalvelongevity aging stress tolerance heterozygosity antarctic genes metabolic rate depression argopecten-irradians-irradians arctica-islandica l antioxidant defense systems mytilus-edulis l. oxidative stress ocean quahog bay scallop laternula-elliptica population-dynamics lipid-peroxidation
Research affiliation: OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
ISSN: 0531-5565
Projects: Future Ocean
Date Deposited: 17 Dec 2010 14:21
Last Modified: 27 Jan 2012 05:02

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