Grecocyclines: New Angucyclines from Streptomycessp. Acta 1362

Paululat, Thomas, Kulik, Andreas, Hausmann, Heike, Karagouni, Amalia D., Zinecker, Heidi, Imhoff, Johannes F. and Fiedler, Hans-Peter (2010) Grecocyclines: New Angucyclines from Streptomycessp. Acta 1362 European Journal of Organic Chemistry, 12 . pp. 2344-2350. DOI 10.1002/ejoc.201000054.

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Abstract

Two novel angucyclines were isolated from the streptomycete Acta 1362. The strain was of particular interest regarding the production of characteristic metabolites that were detected by HPLC-diode array profiling of the extracts. Grecocycline A and B were isolated and their structures were determined. Grecocycline A shows cytotoxic activity and grecocycline B inhibits protein tyrosine phosphatase 1B. Moreover, shunt product grecocyline C was isolated and its structure was determined.

Document Type: Article
Keywords: Microbiology; Polyketides • Biological activity • Structure elucidation • Cytotoxicity
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
DOI etc.: 10.1002/ejoc.201000054
ISSN: 1434-193X
Projects: Future Ocean
Date Deposited: 06 Aug 2010 10:41
Last Modified: 04 Jan 2017 12:31
URI: http://eprints.uni-kiel.de/id/eprint/8760

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