MHC-based mate choice combines good genes and maintenance of MHC polymorphism

Eizaguirre, Christophe, Yeates, S.E., Lenz, T.L., Kalbe, M. and Milinski, M. (2009) MHC-based mate choice combines good genes and maintenance of MHC polymorphism Molecular Ecology, 18 . pp. 3316-3329.

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Polymorphicgenesofthemajorhistocompatibilitycomplex(MHC)areregardedasessential genes for individual fitness under conditions of natural and sexual selection. To test this hypothesis, we investigated the ultimate individual fitness trait — that of reproductive success. We used three-spined sticklebacks (Gasterosteus aculeatus) in seminatural enclosures, located in natural breeding areas where the experimental fish had been caught. During their reproductive period, fish were exposed continuously to their natural sympatric parasites. By genotyping almost 4000 eggs with nine microsatellites, we determined parenthood and inferred female mating decision. We found that with reference to their own MHC profile, female sticklebacks preferred to mate with males sharing an intermediate MHC diversity. In addition, males with a specific MHC haplotype were bigger and better at fighting a common parasite (Gyrodactylus sp.). This translated directly into Darwinian fitness since fish harbouring this specific MHC haplotype were more likely to be chosen and had a higher reproductive output. We conclude that females also based their mating decision on a specific MHChaplotype conferring resistance against a common parasite. This identifies
and supports ‘good genes’. We argue that such an interaction between host and parasite
driving assortative mating is not only a prerequisite for negative frequency-dependent
selection — a potential mechanism to explain the maintenance of MHC polymorphism, but
also potentially speciation.

Document Type: Article
Keywords: female mate choice; good genes; major histocompatibility complex; MHC polymorphism; optimality; reproductive success
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-EV Evolutionary Ecology of Marine Fishes
Refereed: Yes
ISSN: 0962-1083
Date Deposited: 07 Aug 2009 11:04
Last Modified: 31 May 2016 13:40

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