Two different epigenetic information channels in wild three-spined sticklebacks are involved in salinity adaptation

Heckwolf, Melanie J., Meyer, Britta S., Häsler, Robert, Höppner, Marc P., Eizaguirre, Christophe and Reusch, Thorsten B. H. (2020) Two different epigenetic information channels in wild three-spined sticklebacks are involved in salinity adaptation Science Advances, 6 (12). eaaz1138. DOI 10.1126/sciadv.aaz1138.

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Supplementary data:

Abstract

Epigenetic inheritance has been proposed to contribute to adaptation and acclimation via two information channels: (i) inducible epigenetic marks that enable transgenerational plasticity and (ii) noninducible epigenetic marks resulting from random epimutations shaped by selection. We studied both postulated channels by sequencing methylomes and genomes of Baltic three-spined sticklebacks ( Gasterosteus aculeatus ) along a salinity cline. Wild populations differing in salinity tolerance revealed differential methylation (pop-DMS) at genes enriched for osmoregulatory processes. A two-generation experiment demonstrated that 62% of these pop-DMS were noninducible by salinity manipulation, suggesting that they are the result of either direct selection or associated genomic divergence at cis- or trans-regulatory sites. Two-thirds of the remaining inducible pop-DMS increased in similarity to patterns detected in wild populations from corresponding salinities. The level of similarity accentuated over consecutive generations, indicating a mechanism of transgenerational plasticity. While we can attribute natural DNA methylation patterns to the two information channels, their interplay with genomic variation in salinity adaptation is still unresolved.

Document Type: Article
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-EV Marine Evolutionary Ecology
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
DOI etc.: 10.1126/sciadv.aaz1138
ISSN: 2375-2548
Related URLs:
Projects: BAMBI, BONUS, Future Ocean, SPP 1182
Date Deposited: 23 Mar 2020 07:01
Last Modified: 01 Apr 2020 07:22
URI: http://eprints.uni-kiel.de/id/eprint/49282

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