Lithium‐Rich Mineral Water is a Highly Bioavailable Lithium Source for Human Consumption

Seidel, Ulrike, Baumhof, Elena, Hägele, Franziska A., Bosy‐Westphal, Anja, Birringer, Marc and Rimbach, Gerald (2019) Lithium‐Rich Mineral Water is a Highly Bioavailable Lithium Source for Human Consumption Molecular Nutrition & Food Research . p. 1900039. DOI 10.1002/mnfr.201900039.

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Supplementary data:


Lithium is an important trace element in human nutrition and medicine. Mineral and medicinal waters may represent a significant source of dietary lithium intake.
Methods and results
The lithium concentration of 360 German mineral and 21 medicinal waters is determined. Based on a systematic screening, three different mineral waters exhibiting low (1.7 µg L−1), medium (171 µg L−1), and high lithium (1724 µg L−1) concentrations are chosen for an acute bioavailability study in male healthy volunteers. In Germany, a north‐east to south‐west gradient of analyzed lithium concentrations is observed in the 381 tested waters. The lithium concentration in the water is significantly correlated with its sodium (r = 0. 810), potassium (r = 0.716), and magnesium (r = 0.361), but not with its calcium concentration. In a randomized cross‐over trial, volunteers (n = 3×10 each) drink 1.5 L of the respective mineral waters, and lithium concentrations in serum and urine are monitored over 24 h. Consumption of the mineral waters with a medium and high lithium content results in a dose‐dependent response in serum lithium concentrations and total urinary lithium excretion.
Lithium‐rich mineral and medicinal waters may be an important and highly bioavailable lithium source for human consumption.

Document Type: Article
Research affiliation: Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
DOI etc.: 10.1002/mnfr.201900039
ISSN: 1613-4125
Date Deposited: 13 Aug 2019 10:12
Last Modified: 19 Aug 2019 13:56

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