Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy

von Frieling, Jakob, Fink, Christine, Hamm, Jacob, Klischies, Kenneth, Forster, Michael, Bosch, T. C. G., Roeder, Thomas, Rosenstiel, Philip and Sommer, Felix (2018) Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy Frontiers in Microbiology, 9 . DOI 10.3389/fmicb.2018.02020.

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Abstract

The eukaryotic host is in close contact to myriads of resident and transient microbes, which influence the crucial physiological pathways. Emerging evidence points to their role of host–microbe interactions for controlling tissue homeostasis, cell fate decisions, and regenerative capacity in epithelial barrier organs including the skin, lung, and gut. In humans and mice, it has been shown that the malignant tumors of these organs harbor an altered microbiota. Mechanistic studies have shown that the altered metabolic properties and secreted factors contribute to epithelial carcinogenesis and tumor progression. Exciting recent work points toward a crucial influence of the associated microbial communities on the response to chemotherapy and immune-check point inhibitors during cancer treatment, which suggests that the modulation of the microbiota might be a powerful tool for personalized oncology. In this article, we provide an overview of how the bacterial signals and signatures may influence epithelial homeostasis across taxa from cnidarians to vertebrates and delineate mechanisms, which might be potential targets for therapy of human diseases by either harnessing barrier integrity (infection and inflammation) or restoring uncontrolled proliferation (cancer).

Document Type: Article
Keywords: microbiota, proliferation, cancer, chemotherapy, xenobiotics
Research affiliation: Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
DOI etc.: 10.3389/fmicb.2018.02020
ISSN: 1664-302X
Projects: Future Ocean
Date Deposited: 10 Dec 2018 10:33
Last Modified: 10 Dec 2018 10:33
URI: http://eprints.uni-kiel.de/id/eprint/44904

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