Rethinking the Role of the Nervous System: Lessons From the Hydra Holobiont

Klimovich, Alexander V. and Bosch, T. C. G. (2018) Rethinking the Role of the Nervous System: Lessons From the Hydra Holobiont BioEssays, 40 (9). DOI 10.1002/bies.201800060.

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Abstract

Here we evaluate our current understanding of the function of the nervous system in Hydra, a non‐bilaterian animal which is among the first metazoans that contain neurons. We highlight growing evidence that the nervous system, with its rich repertoire of neuropeptides, is involved in controlling resident beneficial microbes. We also review observations that indicate that microbes affect the animal's behavior by directly interfering with neuronal receptors. These findings provide new insight into the original role of the nervous system, and suggest that it emerged to orchestrate multiple functions including host‐microbiome interactions. The excitement of future research in the Hydra model now relies on uncovering the common rules and principles that govern the interaction between neurons and microbes and the extent to which such laws might apply to other and more complex organisms.

Document Type: Article
Keywords: AMPs commensal microbiota host‐microbe interaction Hydra metaorganism nerve system neuropeptides
Research affiliation: Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
DOI etc.: 10.1002/bies.201800060
ISSN: 02659247
Projects: Future Ocean
Date Deposited: 10 Dec 2018 10:28
Last Modified: 10 Dec 2018 10:28
URI: http://eprints.uni-kiel.de/id/eprint/44902

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