The plastid-nucleus located DNA/RNA binding protein WHIRLY1 regulates microRNA-levels during stress in barley (Hordeum vulgare L.)

Świda-Barteczka, Aleksandra, Krieger-Liszkay, Anja, Bilger, Wolfgang, Voigt, Ulrike, Hensel, Götz, Szweykowska-Kulinska, Zofia and Krupinska, Karin (2018) The plastid-nucleus located DNA/RNA binding protein WHIRLY1 regulates microRNA-levels during stress in barley (Hordeum vulgare L.) RNA Biology, 15 (7). pp. 886-891. DOI 10.1080/15476286.2018.1481695.

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Abstract

In this article a novel mechanism of retrograde signaling by chloroplasts during stress is described. This mechanism involves the DNA/RNA binding protein WHIRLY1 as a regulator of microRNA levels. By virtue of its dual localization in chloroplasts and the nucleus of the same cell, WHIRLY1 was proposed as an excellent candidate coordinator of chloroplast function and nuclear gene expression. Comparison of wild-type and transgenic plants with an RNAi-mediated knockdown of WHIRLY1 showed, that the transgenic plants were unable to cope with continuous high light conditions. They were impaired in production of several microRNAs mediating post-transcriptional responses during stress. The results support a central role of WHIRLY1 in retrograde signaling and also underpin a so far underestimated role of microRNAs in this process.

Document Type: Article
Keywords: Retrograde signaling, small RNA, stress response
Research affiliation: Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
DOI etc.: 10.1080/15476286.2018.1481695
ISSN: 1547-6286
Projects: Future Ocean
Date Deposited: 06 Dec 2018 11:11
Last Modified: 06 Dec 2018 11:11
URI: http://eprints.uni-kiel.de/id/eprint/44862

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