Stem Cell Transcription Factor FoxO Controls Microbiome Resilience in Hydra

Mortzfeld, Benedikt M., Taubenheim, Jan, Fraune, Sebastian, Klimovich, Alexander V. and Bosch, T. C. G. (2018) Stem Cell Transcription Factor FoxO Controls Microbiome Resilience in Hydra Frontiers in Microbiology, 9 . DOI 10.3389/fmicb.2018.00629.

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Abstract

The aging process is considered to be the result of accumulating cellular deterioration in an individual organism over time. It can be affected by the combined influence of genetic, epigenetic, and environmental factors including life-style-associated events. In the non-senescent freshwater polyp Hydra, one of the classical model systems for evolutionary developmental biology and regeneration, transcription factor FoxO modulates both stem cell proliferation and innate immunity. This provides strong support for the role of FoxO as a critical rate-of-aging regulator. However, how environmental factors interact with FoxO remains unknown. Here, we find that deficiency in FoxO signaling in Hydra leads to dysregulation of antimicrobial peptide expression and that FoxO loss-of-function polyps are impaired in selection for bacteria resembling the native microbiome and more susceptible to colonization of foreign bacteria. These findings reveal a key role of FoxO signaling in the communication between host and microbiota and embed the evolutionary conserved longevity factor FoxO into the holobiont concept.

Document Type: Article
Research affiliation: Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
DOI etc.: 10.3389/fmicb.2018.00629
ISSN: 1664-302X
Projects: Future Ocean
Date Deposited: 03 Apr 2018 08:33
Last Modified: 03 Apr 2018 08:33
URI: http://eprints.uni-kiel.de/id/eprint/42553

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