Heterogeneity of tight junctions in the thick ascending limb

Bleich, Markus, Wulfmeyer, Vera C., Himmerkus, Nina and Milatz, Susanne (2017) Heterogeneity of tight junctions in the thick ascending limb Annals of the New York Academy of Sciences, 1405 (1). pp. 5-15. DOI 10.1111/nyas.13400.

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Renal tubular transport mechanisms are optimized to be energy efficient and tailored to local gradients and transport rates. The combined transcellular action of ion channels, transporters, and pumps, together with the paracellular pathway, enables kidney function. Monogenetic diseases and mouse models indicate that both trans- and paracellular proteins can become disease-causing candidates and may be targets for future therapeutic approaches. Recent advances in tight junction research have provided new insights into their structure, function, and regulation. The thick ascending limb (TAL) is a nephron segment with specific requirements for the paracellular pathway. It has to fuel the generation of the corticomedullary concentration gradient, to be watertight, and to provide a highly selective permeability for Na+ and divalent cations. Tight junction composition and function in the TAL is organized along the corticomedullary axis. Even on the level of a seemingly homogeneous tubular epithelium like the TAL, there is a separation of tight junction protein expression in the strands between the respective tricellular nexus of the junctional network. Here, we highlight some new insights from our recent work and that of others in this context. In addition, we provide some perspectives for the further study of paracellular transport mechanisms.

Document Type: Article
Research affiliation: Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
DOI etc.: 10.1111/nyas.13400
ISSN: 00778923
Projects: Future Ocean
Date Deposited: 02 Feb 2018 11:25
Last Modified: 08 Feb 2018 07:42
URI: http://eprints.uni-kiel.de/id/eprint/41801

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