Carbamazepine affects water and electrolyte homoeostasis in rat--similarities and differences to vasopressin antagonism

Himmerkus, N., Sievers, B. and Bleich, Markus (2012) Carbamazepine affects water and electrolyte homoeostasis in rat--similarities and differences to vasopressin antagonism Nephrology Dialysis Transplantation, 27 (10). pp. 3790-3798. DOI 10.1093/ndt/gfs107.

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Supplementary data:

Abstract

BACKGROUND:

Carbamazepine (CBZ) is a drug widely used in the therapy of epilepsy and mood disorders. One frequently observed side effect is hyponatraemia. The role of vasopressin in hyponatraemic action of CBZ is discussed controversially. In this study, we tested the influence of CBZ on water and salt homoeostasis in rat under different hydration states and under vasopressin 2 receptor (V2R) antagonism by satavaptan to elucidate the renal and vasopressin independent action of CBZ.
METHODS:

CBZ-treated rats were investigated on metabolic cages after (i) 6 day with ad libitum fluid intake, (ii) moderate water load and (iii) water restriction. The effect of satavaptan was tested in clearance experiments under continuous saline infusion in anaesthetized rats after CBZ pretreatment.
RESULTS:

Compared to controls, CBZ induced a higher urinary flow rate which was most pronounced (20-fold) after water load and significantly elevated (2-fold) after 10-h water restriction. In addition, CBZ consistently increased renal sodium loss but failed to decrease plasma sodium concentration. In the presence of satavaptan, urinary flow and natriuresis were further increased by CBZ, while there was no differential effect on urea excretion and anion gap.
CONCLUSIONS:

At the investigated dose (50 mg/kg body weight), CBZ did not induce hyponatraemia or antidiuresis in the rat. However, depending on the hydration state, it induced an increased water and electrolyte loss. Its enhanced influence on urinary flow and natriuresis in the presence of satavaptan suggests additional renal targets for CBZ, independent of vasopressin signalling.

Document Type: Article
Research affiliation: Kiel University
Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
DOI etc.: 10.1093/ndt/gfs107
ISSN: 0931-0509
Projects: Future Ocean
Date Deposited: 08 Mar 2017 11:00
Last Modified: 08 Mar 2017 11:00
URI: http://eprints.uni-kiel.de/id/eprint/36844

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