Free Radical Scavenging and Cellular Antioxidant Properties of Astaxanthin

Dose, J., Matsugo, S., Yokokawa, H., Koshida, Y., Okazaki, S., Seidel, U., Eggersdorfer, M., Rimbach, Gerald and Esatbeyoglu, T. (2016) Free Radical Scavenging and Cellular Antioxidant Properties of Astaxanthin International Journal of Molecular Sciences, 17 (1). DOI 10.3390/ijms17010103.

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Astaxanthin is a coloring agent which is used as a feed additive in aquaculture nutrition. Recently, potential health benefits of astaxanthin have been discussed which may be partly related to its free radical scavenging and antioxidant properties. Our electron spin resonance (ESR) and spin trapping data suggest that synthetic astaxanthin is a potent free radical scavenger in terms of diphenylpicryl-hydrazyl (DPPH) and galvinoxyl free radicals. Furthermore, astaxanthin dose-dependently quenched singlet oxygen as determined by photon counting. In addition to free radical scavenging and singlet oxygen quenching properties, astaxanthin induced the antioxidant enzyme paroxoanase-1, enhanced glutathione concentrations and prevented lipid peroxidation in cultured hepatocytes. Present results suggest that, beyond its coloring properties, synthetic astaxanthin exhibits free radical scavenging, singlet oxygen quenching, and antioxidant activities which could probably positively affect animal and human health.

Document Type: Article
Additional Information: Times Cited: 7 Dose, Janina Matsugo, Seiichi Yokokawa, Haruka Koshida, Yutaro Okazaki, Shigetoshi Seidel, Ulrike Eggersdorfer, Manfred Rimbach, Gerald Esatbeyoglu, Tuba
Research affiliation: Kiel University
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
DOI etc.: 10.3390/ijms17010103
ISSN: 1422-0067
Projects: Future Ocean
Date Deposited: 01 Mar 2017 08:25
Last Modified: 01 Mar 2017 08:25

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