Antifungal potential of marine natural products

El-Hossary, Ebaa M., Cheng, Cheng, Hamed, Mostafa M., El-Sayed Hamed, Ashraf Nageeb, Ohlsen, Knut, Hentschel, Ute and Abdelmohsen, Usama Ramadan (2017) Antifungal potential of marine natural products European Journal of Medicinal Chemistry, 126 . pp. 631-651. DOI 10.1016/j.ejmech.2016.11.022.

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Supplementary data:


• Fungal infections represent an increasing threat to human health.
• Fungal infections in plants are a worldwide problem to the agricultural industry.
• Diverse antifungal compounds were isolated from different marine organisms.
• The number of new antifungal marine natural products is rapidly developing.
• Marine sponges and bacteria are the predominant sources for antifungal compounds.

Fungal diseases represent an increasing threat to human health worldwide which in some cases might be associated with substantial morbidity and mortality. However, only few antifungal drugs are currently available for the treatment of life-threatening fungal infections. Furthermore, plant diseases caused by fungal pathogens represent a worldwide economic problem for the agriculture industry. The marine environment continues to provide structurally diverse and biologically active secondary metabolites, several of which have inspired the development of new classes of therapeutic agents. Among these secondary metabolites, several compounds with noteworthy antifungal activities have been isolated from marine microorganisms, invertebrates, and algae. During the last fifteen years, around 65% of marine natural products possessing antifungal activities have been isolated from sponges and bacteria. This review gives an overview of natural products from diverse marine organisms that have shown in vitro and/or in vivo potential as antifungal agents, with their mechanism of action whenever applicable. The natural products literature is covered from January 2000 until June 2015, and we are reporting the chemical structures together with their biological activities, as well as the isolation source.

Document Type: Article
Keywords: Marine microorganisms; Marine invertebrates; Marine natural products; Secondary metabolites; Fungal infections; Antifungal activity
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
Refereed: Yes
DOI etc.: 10.1016/j.ejmech.2016.11.022
ISSN: 0223-5234
Projects: SeaBioTech, SFB630, Future Ocean
Date Deposited: 04 Jan 2017 09:06
Last Modified: 19 Dec 2017 12:44

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