New Pentaenes from the Sponge-Derived Marine Fungus Penicillium rugulosum: Structure Determination and Biosynthetic Studies

Lang, Gerhard, Wiese, Jutta, Schmaljohann, Rolf and Imhoff, Johannes F. (2007) New Pentaenes from the Sponge-Derived Marine Fungus Penicillium rugulosum: Structure Determination and Biosynthetic Studies Tetrahedron, 63 . pp. 11844-11849. DOI 10.1016/j.tet.2007.09.025.

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Abstract

Seven new fungal polyketides possessing linear pentaene structures ending in cyclic moieties were isolated from the mycelium extract of a marine sponge-derived Penicillium rugulosum. Feeding of C-13-labeled acetate and L-methionine was used to verify the polyketide origin of prugosene A1. It could also be shown that prugosenes B1 and C1 were formed from prugosene A1 by hydrolysis and decarboxylation of its oxabicyclo[2.2.1]heptane unit.

Document Type: Article
Additional Information: WOS:000252094500007
Keywords: penicillium; natural product; polyketide; biosynthesis; ALKALOIDS; STRAIN
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > GEOMAR > Applied R&D > Centre for Marine Substances (KiWiZ)
Refereed: Yes
DOI etc.: 10.1016/j.tet.2007.09.025
ISSN: 0040-4020
Projects: KIWIZ, Future Ocean
Date Deposited: 03 Dec 2008 16:51
Last Modified: 05 Dec 2017 12:00
URI: http://eprints.uni-kiel.de/id/eprint/3258

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