Psoriasis and Cardiometabolic Traits: Modest Association but Distinct Genetic Architectures

Koch, Manja, Baurecht, Hansjoerg, Ried, Janina S., Rodriguez, Elke, Schlesinger, Sabrina, Volks, Natalie, Gieger, Christian, Rueckert, Ina-Maria, Heinrich, Luise, Willenborg, Christina, Smith, Catherine, Peters, Annette, Thorand, Barbara, Koenig, Wolfgang, Lamina, Claudia, Jansen, Henning, Kronenberg, Florian, Seissler, Jochen, Thiery, Joachim, Rathmann, Wolfgang, Schunkert, Heribert, Erdmann, Jeanette, Barker, Jonathan, Nair, Rajan P., Tsoi, Lam C., Elder, James T., Mrowietz, Ulrich, Weichenthal, Michael, Mucha, Soeren, Schreiber, Stefan, Franke, Andre, Schmitt, Jochen, Lieb, Wolfgang and Weidinger, Stephan (2015) Psoriasis and Cardiometabolic Traits: Modest Association but Distinct Genetic Architectures Journal of Investigative Dermatology, 135 (5). pp. 1283-1293.

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Psoriasis has been linked to cardiometabolic diseases, but epidemiological findings are inconsistent. We investigated the association between psoriasis and cardiometabolic outcomes in a German cross-sectional study (n = 4,185) and a prospective cohort of German Health Insurance beneficiaries (n=1,811,098). A potential genetic overlap was explored using genome-wide data from >22,000 coronary artery disease and >4,000 psoriasis cases, and with a dense genotyping study of cardiometabolic risk loci on 927 psoriasis cases and 3,717 controls. After controlling for major confounders, in the cross-sectional analysis psoriasis was significantly associated with type 2 diabetes (T2D, adjusted odds ratio (OR) = 2.36; 95% confidence interval CI=1.26-4.41) and myocardial infarction (MI, OR=2.26; 95% CI=1.03-4.96). In the longitudinal study, psoriasis slightly increased the risk for incident T2D (adjusted relative risk (RR) = 1.11; 95% CI = 1.08-1.14) and MI (RR=1.14; 95% CI=1.06-1.22), with highest risk increments in systemically treated psoriasis, which accounted for 11 and 17 excess cases of T2D and MI per 10,000 person-years. Except for weak signals from within the major histocompatibility complex, there was no evidence of genetic risk loci shared between psoriasis and cardiometabolic traits. Our findings suggest that psoriasis, in particular severe psoriasis, increases the risk for T2D and MI, and that the genetic architecture of psoriasis and cardiometabolic traits is largely distinct.

Document Type: Article
Additional Information: Times Cited: 3
Research affiliation: Kiel University
OceanRep > The Future Ocean - Cluster of Excellence
ISSN: 0022-202X
Projects: Future Ocean
Date Deposited: 18 Oct 2016 03:46
Last Modified: 18 Oct 2016 03:46

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