The following databases were mined to identify human proteins that require cofactors:
- EBI CoFactor
https://www.ebi.ac.uk/thornton-srv/databases/CoFactor/
- Uniprot
http://www.ebi.ac.uk/uniprot/index.html
- Expasy
http://enzyme.expasy.org/
- Metal MACiE
http://www.ebi.ac.uk/thornton-srv/databases/MACiE/index.html

The protein-protein interaction network was constructed with data from i2d database:
http://ophid.utoronto.ca/ophidv2.204/

The RNAseq data for 16 different tissues of the Human BodyMap 2.0 was downloaded from the Illumina database (GEO GSE30611):
http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE30611

Tissue-specific expression of cofactor-interacting proteins was evaluated using data extracted from the Human Protein Atlas (HPA) database:
http://www.proteinatlas.org/

The links between cofactor-interacting proteins and diseases were inferred from the DiseaseConnect database:
http://www.disease-connect.org/

Databases obtained by combining all information available from the public repositories listed above are available as Supplementary information of the journal:
http://www.nature.com/articles/srep19633#supplementary-information
See the following files:
srep19633-s2.xlsx
srep19633-s3.xlsx
srep19633-s4.xlsx
srep19633-s5.xlsx
srep19633-s6.xlsx