Diversity of key players in the microbial ecosystems of the human body

Jordán, Ferenc, Lauria, Mario, Scotti, Marco, Nguyen, Thanh-Phuong, Praveen, Paurush, Morine, Melissa and Priami, Corrado (2015) Diversity of key players in the microbial ecosystems of the human body Scientific Reports, 5 . p. 15920. DOI 10.1038/srep15920.

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Abstract

Coexisting bacteria form various microbial communities in human body parts. In these ecosystems they interact in various ways and the properties of the interaction network can be related to the stability and functional diversity of the local bacterial community. In this study, we analyze the interaction network among bacterial OTUs in 11 locations of the human body. These belong to two major groups. One is the digestive system and the other is the female genital tract. In each local ecosystem we determine the key species, both the ones being in key positions in the interaction network and the ones that dominate by frequency. Beyond identifying the key players and discussing their biological relevance, we also quantify and compare the properties of the 11 networks. The interaction networks of the female genital system and the digestive system show totally different architecture. Both the topological properties and the identity of the key groups differ. Key groups represent four phyla of prokaryotes. Some groups appear in key positions in several locations, while others are assigned only to a single body part. The key groups of the digestive and the genital tracts are totally different.

Document Type: Article
Additional Information: The OTU census data used in the manuscript are based on 16S variable region 3-5 (V35) and were downloaded from the Human Microbiome Project (http://hmpdacc.org) database. WOS:000363754300001
Keywords: HUMAN GUT MICROBIOME; INFLAMMATORY-BOWEL-DISEASE; GASTROINTESTINAL-TRACT; BACTERIAL INTERACTIONS; CLOSTRIDIUM-DIFFICILE; PROTEIN NETWORKS; HUMAN INTESTINE; ENTEROTYPES; MODULATION; PATTERNS
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-EOE-N Experimental Ecology - Food Webs
Refereed: Yes
DOI etc.: 10.1038/srep15920
ISSN: 2045-2322
Related URLs:
Projects: Future Ocean
Date Deposited: 23 Nov 2015 12:19
Last Modified: 19 Dec 2017 12:50
URI: http://eprints.uni-kiel.de/id/eprint/30323

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