Azathioprine in Crohn's disease therapy - guidance against the background of recent studies

Schmidt, C., Herrlinger, K., Siegmund, B., Bokemeyer, B., Schreiber, Stefan and Stallmach, A. (2014) Azathioprine in Crohn's disease therapy - guidance against the background of recent studies Zeitschrift Fur Gastroenterologie, 52 (12). pp. 1423-1430.

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Abstract

Thiopurines (azathioprine and 6-mercaptopurine) are the most frequently used drugs in the treatment of patients with Crohn's disease. In current guidelines published by the German Society of Gastroenterology, Nutritional and Metabolic Diseases (DGVS) in 2014 and by the European Crohn's and Colitis Organisation (ECCO) in 2010 different indications have been suggested. However, efficacy of azathioprine has been substantially questioned by recent publications in adults as well as in children examining the efficacy of early initiation of this treatment. These articles were published after release of the aforementioned guidelines. Therefore, in this survey recently published data are discussed on the background of our knowledge on the efficacy of azathioprine and 6-mercaptopurine developed in many years, and suggestions for the future use of these substances in the treatment of patients with Crohn's disease will be provided.

Document Type: Article
Additional Information: Times Cited: 0 0
Research affiliation: Kiel University > Faculty of Medicine > Institute of Clinical Molecular Biology
OceanRep > The Future Ocean - Cluster of Excellence
ISSN: 0044-2771
Projects: Future Ocean
Date Deposited: 30 Mar 2015 12:43
Last Modified: 30 Mar 2015 12:43
URI: http://eprints.uni-kiel.de/id/eprint/28174

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