Populational equilibrium through exosome-mediated Wnt signaling in tumor progression of diffuse large B-cell lymphoma

Koch, Raphael, Demant, Martin, Aung, Thiha, Diering, Nina, Cicholas, Anna, Chapuy, Bjoern, Wenzel, Dirk, Lahmann, Marlen, Guentsch, Annemarie, Kiecke, Christina, Becker, Sabrina, Hupfeld, Timo, Venkataramani, Vivek, Ziepert, Marita, Opitz, Lennart, Klapper, Wolfram, Truemper, Lorenz and Wulf, Gerald G. (2014) Populational equilibrium through exosome-mediated Wnt signaling in tumor progression of diffuse large B-cell lymphoma Blood, 123 (14). pp. 2189-2198.

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Abstract

Tumors are composed of phenotypically heterogeneous cell populations. The non-genomic mechanisms underlying transitions and interactions between cell populations are largely unknown. Here, we show that diffuse large B-cell lymphomas possess a self-organized infrastructure comprising side population (SP) and non-SP cells, where transitions between clonogenic states are modulated by exosome-mediated Wnt signaling. DNA methylation modulated SP-non-SP transitions and was correlated with the reciprocal expressions of Wnt signaling pathway agonist Wnt3a in SP cells and the antagonist secreted frizzled-related protein 4 in non-SP cells. Lymphoma SP cells exhibited autonomous clonogenicity and exported Wnt3a via exosomes to neighboring cells, thus modulating population equilibrium in the tumor.

Document Type: Article
Additional Information: Times Cited: 0 0
ISSN: 0006-4971
Date Deposited: 30 Mar 2015 12:29
Last Modified: 30 Mar 2015 12:29
URI: http://eprints.uni-kiel.de/id/eprint/27777

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