Successful application of belimumab in two patients with systemic lupus erythematosus experiencing a flare during tocilizumab treatment

Jueptner, M., Zeuner, R., Schreiber, Stefan, Laudes, M. and Schroeder, J. O. (2014) Successful application of belimumab in two patients with systemic lupus erythematosus experiencing a flare during tocilizumab treatment Lupus, 23 (4). pp. 428-430.

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Abstract

This case report describes two female lupus patients who both received biological treatment with tocilizumab and with belimumab. The disease course was remarkably similar in both cases. Tocilizumab resulted in a transient improvement in pleurisy and arthritis but was then followed by a clinical flare accompanied by an increase in autoantibodies and a drop in complement levels. Alike, both patients experienced a rapid and sustained improvement after institution of belimumab. The clinical benefit obtained is currently stable under ongoing belimumab therapy.

Document Type: Article
Additional Information: Times Cited: 0 Laudes, Matthias/C-8885-2011 0
Research affiliation: Kiel University
OceanRep > The Future Ocean - Cluster of Excellence
ISSN: 0961-2033
Projects: Future Ocean
Date Deposited: 30 Mar 2015 12:27
Last Modified: 30 Mar 2015 12:27
URI: http://eprints.uni-kiel.de/id/eprint/27736

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