MicroRNAs and their relevance to ABC transporters

Haenisch, Sierk, Werk, Anneke Nina and Cascorbi, Ingolf (2014) MicroRNAs and their relevance to ABC transporters British Journal of Clinical Pharmacology, 77 (4). pp. 587-596.

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Abstract

MicroRNAs (miRNAs) are small noncoding RNAs, which regulate the expression of their target genes post-transcriptionally by RNA interference. They are involved in almost all cellular processes, including proliferation, differentiation, apoptosis, cell survival and the maintenance of tissue specificity. Recent findings also suggest that efflux pumps of the ABC (ATP-binding cassette) transporter family are subject to miRNA-mediated gene regulation. Moreover, it seems that ABC transporters are embedded in a concerted and miRNA-guided network of concurrently regulated proteins that mediate altered drug transport and cell survival in changing environmental conditions. In this review, we summarize recent findings of miRNAs interacting with ABC transporters, which have been connected with drug distribution as well as with drug resistance. Additionally, we specify findings of complex miRNA-protein pathways conferring increased drug export and cell survival.

Document Type: Article
Additional Information: Times Cited: 2 SI Haenisch, Sierk/I-4689-2012 0 2
Research affiliation: OceanRep > The Future Ocean - Cluster of Excellence
ISSN: 0306-5251
Projects: Future Ocean
Date Deposited: 30 Mar 2015 12:18
Last Modified: 30 Mar 2015 12:18
URI: http://eprints.uni-kiel.de/id/eprint/27607

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