Species-Specific Viromes in the Ancestral Holobiont Hydra

Grasis, Juris A., Lachnit, Tim, Anton-Erxleben, Friederike, Lim, Yan Wei, Schmieder, Robert, Fraune, Sebastian, Franzenburg, Soeren, Insua, Santiago, Machado, GloriaMay, Haynes, Matthew, Little, Mark, Kimble, Robert, Rosenstiel, Philip, Rohwer, Forest L. and Bosch, Thomas (2014) Species-Specific Viromes in the Ancestral Holobiont Hydra PLoS ONE, 9 (10).

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Abstract

Recent evidence showing host specificity of colonizing bacteria supports the view that multicellular organisms are holobionts comprised of the macroscopic host in synergistic interdependence with a heterogeneous and host-specific microbial community. Whereas host-bacteria interactions have been extensively investigated, comparatively little is known about host-virus interactions and viral contribution to the holobiont. We sought to determine the viral communities associating with different Hydra species, whether these viral communities were altered with environmental stress, and whether these viruses affect the Hydra-associated holobiont. Here we show that each species of Hydra harbors a diverse host-associated virome. Primary viral families associated with Hydra are Myoviridae, Siphoviridae, Inoviridae, and Herpesviridae. Most Hydra-associated viruses are bacteriophages, a reflection of their involvement in the holobiont. Changes in environmental conditions alter the associated virome, increase viral diversity, and affect the metabolism of the holobiont. The specificity and dynamics of the virome point to potential viral involvement in regulating microbial associations in the Hydra holobiont. While viruses are generally regarded as pathogenic agents, our study suggests an evolutionary conserved ability of viruses to function as holobiont regulators and, therefore, constitutes an emerging paradigm shift in host-microbe interactions.

Document Type: Article
Additional Information: Times Cited: 0 0
Research affiliation: Kiel University
UNSPECIFIED
Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
ISSN: 1932-6203
Projects: Future Ocean
Date Deposited: 30 Mar 2015 12:17
Last Modified: 08 Feb 2018 12:54
URI: http://eprints.uni-kiel.de/id/eprint/27595

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