Genetics of Sarcoidosis

Fischer, Annegret, Grunewald, Johan, Spagnolo, Paolo, Nebel, Almut, Schreiber, Stefan and Mueller-Quernheim, Joachim (2014) Genetics of Sarcoidosis Seminars in Respiratory and Critical Care Medicine, 35 (3). pp. 296-306.

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Abstract

Sarcoidosis is a multifactorial and polygenic disorder. Recently, several novel predisposing genes have been identified by genome-wide association studies, and fast progress in molecular technologies such as systematic and large-scale resequencing will aid the discovery of further risk loci and variants. In this article, the current knowledge of its genetics will be presented, including known and candidate risk variants and loci, with a focus on loci in the human leukocyte antigen region. Some of these factors are shared with other, clinically distinct diseases. This May lead to the development of new hypotheses on pathomechanisms, which associate sarcoidosis with other granulomatous disorders but also with diseases with significantly different phenotypes. In the near future system, biology approaches. will help unravel the differing and common features of these disorders and allow the development of new therapeutic Strategies and tools to predict the course and response to treatment of individual patients.

Document Type: Article
Additional Information: Times Cited: 0 Nebel, Almut/E-4196-2010 0
Research affiliation: Kiel University
OceanRep > The Future Ocean - Cluster of Excellence
ISSN: 1069-3424
Projects: Future Ocean
Date Deposited: 30 Mar 2015 12:11
Last Modified: 30 Mar 2015 12:11
URI: http://eprints.uni-kiel.de/id/eprint/27523

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