Naturally occurring tumours in the basal metazoan Hydra

Domazet-Loso, Tomislav, Klimovich, Alexander, Anokhin, Boris, Anton-Erxleben, Friederike, Hamm, Mailin J., Lange, Christina and Bosch, Thomas (2014) Naturally occurring tumours in the basal metazoan Hydra Nature Communications, 5 .

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Abstract

The molecular nature of tumours is well studied in vertebrates, although their evolutionary origin remains unknown. In particular, there is no evidence for naturally occurring tumours in pre-bilaterian animals, such as sponges and cnidarians. This is somewhat surprising given that recent computational studies have predicted that most metazoans might be prone to develop tumours. Here we provide first evidence for naturally occurring tumours in two species of Hydra. Histological, cellular and molecular data reveal that these tumours are transplantable and might originate by differentiation arrest of female gametes. Growth of tumour cells is independent from the cellular environment. Tumour-bearing polyps have significantly reduced fitness. In addition, Hydra tumours show a greatly altered transcriptome that mimics expression shifts in vertebrate cancers. Therefore, this study shows that spontaneous tumours have deep evolutionary roots and that early branching animals may be informative in revealing the fundamental mechanisms of tumorigenesis.

Document Type: Article
Additional Information: Times Cited: 0 0
Research affiliation: Kiel University
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
ISSN: 2041-1723
Projects: Future Ocean
Date Deposited: 30 Mar 2015 12:09
Last Modified: 03 Nov 2016 12:29
URI: http://eprints.uni-kiel.de/id/eprint/27480

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