Rethinking the role of immunity: lessons from Hydra

Bosch, T. C. G. (2014) Rethinking the role of immunity: lessons from Hydra Trends in Immunology, 35 (10). pp. 495-502.

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Abstract

The ability of multicellular organisms to detect and respond to microorganisms is fundamental and has ancient evolutionary origins. In this review, I evaluate our current understanding of the evolution of epithelial-based innate immunity in Hydra, an apparently simple animal that shares deep evolutionary connections with all animals, including humans. I highlight growing evidence that the innate immune system with its host-specific antimicrobial peptides and rich repertoire of pattern recognition receptors has evolved in response to the need for controlling resident beneficial microbes rather than to defend against invasive pathogens. These findings provide new insight into how developmental pathways beyond those associated with the immune system, such as stem cell transcriptional programs, interact with environmental cues such as microbes.

Document Type: Article
Additional Information: Times Cited: 1 0 1
Research affiliation: Kiel University
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
ISSN: 1471-4906
Projects: Future Ocean
Date Deposited: 30 Mar 2015 12:00
Last Modified: 03 Nov 2016 12:31
URI: http://eprints.uni-kiel.de/id/eprint/27210

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