IL-6 trans-Signaling-Dependent Rapid Development of Cytotoxic CD8(+) T Cell Function

Boettcher, Jan P., Schanz, Oliver, Garbers, Christoph, Zaremba, Anne, Hegenbarth, Silke, Kurts, Christian, Beyer, Marc, Schultze, Joachim L., Kastenmueller, Wolfgang, Rose-John, Stefan and Knolle, Percy A. (2014) IL-6 trans-Signaling-Dependent Rapid Development of Cytotoxic CD8(+) T Cell Function Cell Reports, 8 (5). pp. 1318-1327.

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Abstract

Immune control of infections with viruses or intracellular bacteria relies on cytotoxic CD8(+) T cells that use granzyme B (GzmB) for elimination of infected cells. During inflammation, mature antigen-presenting dendritic cells instruct naive T cells within lymphoid organs to develop into effector T cells. Here, we report a mechanistically distinct and more rapid process of effector T cell development occurring within 18 hr. Such rapid acquisition of effector T cell function occurred through cross-presenting liver sinusoidal endothelial cells (LSECs) in the absence of innate immune stimulation and known costimulatory signaling. Rather, interleukin-6 (IL-6) trans-signaling was required and sufficient for rapid induction of GzmB expression in CD8(+) T cells. Such LSEC-stimulated GzmB-expressing CD8(+) T cells further responded to inflammatory cytokines, eliciting increased and protracted effector functions. Our findings identify a role for IL-6 trans-signaling in rapid generation of effector function in CD8(+) T cells that may be beneficial for vaccination strategies.

Document Type: Article
Additional Information: Times Cited: 0 0
ISSN: 2211-1247
Date Deposited: 30 Mar 2015 12:00
Last Modified: 30 Mar 2015 12:00
URI: http://eprints.uni-kiel.de/id/eprint/27206

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