Immune stimulation in European sea bass (Dicentrarchus labrax) larvae by administration of Poly-ß-hydroxybutyrate (PHB)

Franke, Andrea, Roth, Olivia, de Schryver, Peter and Clemmesen, Catriona (2015) Immune stimulation in European sea bass (Dicentrarchus labrax) larvae by administration of Poly-ß-hydroxybutyrate (PHB) [Poster] In: 17. International Conference on Diseases of Fish and Shellfish (EAFP), 07.-11.09.2015, Las Palmas, Gran Canaria.

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Abstract

Global aquaculture production is growing rapidly, however, the industry is facing great challenges such as high mortality rates during early life stages. The lack of a fully mature immune system makes larvae highly sensitive to infectious diseases. One of the most common pathogenic bacteria in larviculture is Vibrio anguillarum causing worldwide severe economic losses. Due to the development of antibiotic resistances, the establishment of alternative methods to prevent and control diseases, ensure efficient growth and reach maximal survival rates is mandatory to optimize aquaculture productivity. A promising solution might be the early activation of the immature immune system of fish larvae by administration of immunostimulants as nutritional supplements. In our study we assessed the potential immunomodulatory effect of poly-ß-hydroxybutyrate (PHB) in European sea bass (Dicentrarchus labrax) larvae. PHB is a bacterial energy storage compound which may have a potential application as an immunostimulant in fish culture. In our experiment we used rotifers as live carriers to feed PHB-accumulating bacteria (Alcaligenes eutrophus) to first-feeding European sea bass larvae over a period of 14 days. To estimate the immediate impact of PHB, larval mortality rates were monitored daily during the course of the experiment. In order to assess the disease resistance of the larvae, survival rates after bath challenge with Vibrio anguillarum after 3 and 14 days of PHB treatment and 7 days post PHB treatment were monitored. Furthermore, we determined gene expression profiles for immune genes as well as metabolism- and stress-related genes. Results will be discussed in respect to the use of PHB in fish hatcheries and its effect on the immune system of first feeding sea bass.

Document Type: Conference or Workshop Item (Poster)
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-EV Evolutionary Ecology of Marine Fishes
Projects: FINE-Aqua
Date Deposited: 05 Jan 2015 14:02
Last Modified: 22 Dec 2015 09:24
URI: http://eprints.uni-kiel.de/id/eprint/26662

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