Extensive copy-number variation of young genes across stickleback populations

Chain, F. J. J., Feulner, P. G. D., Panchal, M., Eizaguirre, Christophe, Samonte, I. E., Kalbe, M., Lenz, T. L., Stoll, M., Bornberg-Bauer, E., Milinski, M. and Reusch, Thorsten B.H. (2014) Extensive copy-number variation of young genes across stickleback populations PLoS Genetics, 10 (12). e1004830. DOI 10.1371/journal.pgen.1004830.

[img]
Preview
Text
Chain_F_etal_2014PloS_Genetics.pdf - Published Version
Available under License Creative Commons Attribution.

Download (1160Kb) | Preview

Supplementary data:

Abstract

Duplicate genes emerge as copy-number variations (CNVs) at the population level, and remain copy-number polymorphic until they are fixed or lost. The successful establishment of such structural polymorphisms in the genome plays an important role in evolution by promoting genetic diversity, complexity and innovation. To characterize the early evolutionary stages of duplicate genes and their potential adaptive benefits, we combine comparative genomics with population genomics analyses to evaluate the distribution and impact of CNVs across natural populations of an eco-genomic model, the three-spined stickleback. With whole genome sequences of 66 individuals from populations inhabiting three distinct habitats, we find that CNVs generally occur at low frequencies and are often only found in one of the 11 populations surveyed. A subset of CNVs, however, displays copy-number differentiation between populations, showing elevated within-population frequencies consistent with local adaptation. By comparing teleost genomes to identify lineage-specific genes and duplications in sticklebacks, we highlight rampant gene content differences among individuals in which over 30% of young duplicate genes are CNVs. These CNV genes are evolving rapidly at the molecular level and are enriched with functional categories associated with environmental interactions, depicting the dynamic early copy-number polymorphic stage of genes during population differentiation.

Document Type: Article
Additional Information: WOS:000346649900035
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-EV Evolutionary Ecology of Marine Fishes
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
DOI etc.: 10.1371/journal.pgen.1004830
ISSN: 1553-7404
Projects: Future Ocean
Date Deposited: 20 Nov 2014 11:23
Last Modified: 14 Nov 2016 14:08
URI: http://eprints.uni-kiel.de/id/eprint/26055

Actions (login required)

View Item View Item

Document Downloads

More statistics for this item...