Acetylcholinesterase Inhibitors from a Marine Fungus Talaromyces sp. Strain LF458

Wu, Bin, Ohlendorf, Birgit, Oesker, Vanessa, Wiese, Jutta, Malien, Susann, Schmaljohann, Rolf and Imhoff, Johannes F. (2015) Acetylcholinesterase Inhibitors from a Marine Fungus Talaromyces sp. Strain LF458 Marine Biotechnology, 17 (1). pp. 110-119. DOI 10.1007/s10126-014-9599-3.

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Supplementary data:


Two new oxaphenalenone dimers, talaromycesone A (1) and talaromycesone B (2), and a new isopentenyl xanthenone, talaroxanthenone (3), together with six known diphenyl ether derivatives, e.g., Δ1′,3′,-1′-dehydroxypenicillide (4), 1′,2′-dehydropenicillide (5), vermixocin A (6), vermixocin B (7), 3′-methoxy-1′2′-dehydropenicillide (8), and AS-186c (9), were isolated from the culture broth and mycelia of a marine fungus Talaromyces sp. strain LF458. Compound 2 represents the first example of 1-nor oxaphenalenone dimer carbon skeleton. All isolated compounds were subjected to bioactivity assays. Compounds 1, 2, and 9 exhibited potent antibacterial activities with IC50 3.70, 17.36, and 1.34 μM, respectively, against human pathogenic Staphylococcus strains. Compounds 1, 3, and 9 displayed potent acetylcholinesterase inhibitory activities with IC50 7.49, 1.61, and 2.60 μM, respectively. Interestingly, phosphodiesterase PDE-4B2 was inhibited by compounds 3 (IC50 7.25 μM) and 9 (IC50 2.63 μM).

Document Type: Article
Additional Information: WOS:000348132100010; Supplementary information:(10126_2014_9599_MOESM1_ESM.doc (2320896)): Include 32 figures (Fig. S1 – Fig. S32) showing all NMR spectra and HPLC chromatograms, which represent the raw data for the respective tables and paragraphs in the publication.
Keywords: Oxaphenalenone; Isopentenyl xanthenone; Talaromyces; Acetylcholinesterase; Phosphodiesterase
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > GEOMAR > Applied R&D > Centre for Marine Substances (KiWiZ)
Refereed: Yes
DOI etc.: 10.1007/s10126-014-9599-3
ISSN: 1436-2228
Projects: KIWIZ
Date Deposited: 14 Aug 2014 08:32
Last Modified: 13 Apr 2017 09:28

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