Activation of the Caenorhabditis elegans FOXO family transcription factor DAF-16 by pathogenic Bacillus thuringiensis

Wang, Jun, Nakad, Rania and Schulenburg, Hinrich (2012) Activation of the Caenorhabditis elegans FOXO family transcription factor DAF-16 by pathogenic Bacillus thuringiensis Developmental and Comparative Immunology, 37 (1). pp. 193-201.

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Abstract

The FOXO family of transcription factors have recently been implicated in innate immunity, especially in case of DAF-16 from the nematode Caenorhabditis elegans. However, previous studies with this nematode proposed that DAF-16 is not directly activated by pathogens. Rather, DAF-16 mediates resistance if activated by some other cue as part of a general stress response. We specifically tested this notion by analysis of DAF-16 nuclear translocation and thus regulatory activity upon exposure to pathogenic Bacillus thuringiensis. Our results demonstrate that DAF-16 nuclear translocation is indeed particularly induced in response to bacterial pathogenicity, whereas infection load alone has little effect. Translocation is strongest at an early time point, suggesting a role during the immediate immune response. The increased DAF-16 availability is associated with higher resistance and a reduction in feeding behaviour. Taken together, our data highlight that a FOXO transcription factor directly responds to pathogens and thus contributes to immune defence. (C) 2011 Elsevier Ltd. All rights reserved.

Document Type: Article
Research affiliation: Kiel University > Kiel Marine Science
OceanRep > The Future Ocean - Cluster of Excellence
Kiel University
Refereed: Yes
ISSN: 0145-305X
Projects: Future Ocean
Date Deposited: 14 May 2014 09:11
Last Modified: 10 Apr 2018 09:32
URI: http://eprints.uni-kiel.de/id/eprint/24289

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