Thermodynamic and kinetic stabilization of divanadate in the monovanadate/divanadate equilibrium using a Zn-cyclene derivative: Towards a simple ATP synthase model

Sell, H., Gehl, A., Sönnichsen, F. D. and Herges, R. (2012) Thermodynamic and kinetic stabilization of divanadate in the monovanadate/divanadate equilibrium using a Zn-cyclene derivative: Towards a simple ATP synthase model Beilstein Journal of Organic Chemistry, 8 . pp. 81-89.

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Abstract

For the condensation of anions such as phosphate and ADP to form ATP and water, nature employs sophisticated supramolecular systems to overcome coulomb repulsion and activation barriers. For an attempt to create a simple, analogous chemical system, the dimerization of vanadate is probably the simplest model. We have investigated Zn-benzylcyclene which favors the dimerization thermodynamically as shown by NMR titration. Moreover, EXSY NMR experiments reveal that the vanadate dimer is also kinetically stabilized with respect to hydrolysis by complexation with Zn-cyclene.

Document Type: Article
Additional Information: Univ Kiel, Otto Diels Inst Organ Chem, D-24418 Kiel, Germany. Herges, R (reprint author), Univ Kiel, Otto Diels Inst Organ Chem, Otto Hahn Pl 4, D-24418 Kiel, Germany. rherges@oc.uni-kiel.de
Keywords: EXSY NMR NMR titration supramolecular chemistry vanadate condensation (51)V NMR Zn-cyclene supramolecular catalysis phosphoryl transfer transition-state phosphate nmr complexes mechanism intermediate polyamine magnesium
Research affiliation: OceanRep > The Future Ocean - Cluster of Excellence
ISSN: 1860-5397
Projects: Future Ocean
Date Deposited: 14 May 2014 09:36
Last Modified: 29 Jul 2014 08:40
URI: http://eprints.uni-kiel.de/id/eprint/24258

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