Geranylphenazinediol, an Acetylcholinesterase Inhibitor Produced by a Streptomyces Species

Ohlendorf, Birgit, Schulz, Dirk, Erhard, Arlette, Nagel, Kerstin and Imhoff, Johannes F. (2012) Geranylphenazinediol, an Acetylcholinesterase Inhibitor Produced by a Streptomyces Species Journal of Natural Products, 75 (7). pp. 1400-1404. DOI 10.1021/np2009626.

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Abstract

Geranylphenazinediol (1), a new phenazine natural product, was produced by the Streptomyces sp. strain LB 173, which was isolated from a marine sediment sample. The structure was established by analysis of NMR and MS data 1 inhibited the enzyme acetylcholinesterase in the low micromolar range and showed weak antibacterial activity. In order to get a more detailed picture of the activity profile of 1, its inhibitory potential was compared to that of related structures.

Document Type: Article
Keywords: microbiology; Geranylphenazinediol; Streptomyces sp. strain LB173
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > GEOMAR > Applied R&D > Centre for Marine Substances (KiWiZ)
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
DOI etc.: 10.1021/np2009626
ISSN: 0163-3864
Projects: KIWIZ, Future Ocean
Date Deposited: 14 May 2014 10:10
Last Modified: 21 Nov 2016 15:07
URI: http://eprints.uni-kiel.de/id/eprint/24136

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