Programmed necrosis in acute kidney injury

Linkermann, Andreas, De Zen, Federica, Weinberg, Joel, Kunzendorf, Ulrich and Krautwald, Stefan (2012) Programmed necrosis in acute kidney injury Nephrology Dialysis Transplantation, 27 (9). pp. 3412-3419.

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Programmed cell death (PCD) had been widely used synonymously to caspase-mediated apoptosis until caspase-independent cell death was described. Identification of necrosis as a regulated process in ischaemic conditions has recently changed our understanding of PCD. At least three pathways of programmed necrosis (PN) have been identified. First, receptor-interacting protein kinase 3 (RIP3)-dependent necroptosis causes organ failure following stroke, myocardial infarction and renal ischaemia/reperfusion injury. Necroptosis can be mediated either by a large intracellular caspase-8-containing signalling complex called the ripoptosome or by the RIP1-/RIP3-containing necroptosome and is controlled by a caspase-8/FLICE inhibitory protein(long) heterodimer at least in the latter case. Second, mitochondrial permeability transition mediates apoptotic or necrotic stimuli and depends on the mitochondrial protein cyclophilin D. The third PN pathway involves the poly(ADP-ribose) polymerase-calpain axis that contributes to acute kidney injury (AKI). Preclinical interference with the PN pathways therefore raises expectations for the future treatment of ischaemic conditions. In this brief review, we aim to summarize the clinically relevant PCD pathways and to transfer the basic science data to settings of AKI. We conclude that pathologists were quite right to refer to ischaemic kidney injury as oacute tubular necrosis'.

Document Type: Article
Research affiliation: OceanRep > The Future Ocean - Cluster of Excellence
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ISSN: 0931-0509
Projects: Future Ocean
Date Deposited: 14 May 2014 09:50
Last Modified: 14 May 2014 09:50

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