A variant in the heart-specific fatty acid transport protein 6 is associated with lower fasting and postprandial TAG, blood pressure and left ventricular hypertrophy

Auinger, A., Helwig, U., Pfeuffer, M., Rubin, D., Luedde, M., Rausche, T., El Mokhtari, N. E., Folsch, U. R., Schreiber, Stefan, Frey, N. and Schrezenmeir, J. (2012) A variant in the heart-specific fatty acid transport protein 6 is associated with lower fasting and postprandial TAG, blood pressure and left ventricular hypertrophy British Journal of Nutrition, 107 (10). pp. 1422-1428.

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Abstract

Fatty acid transport protein 6 (FATP6) is primarily expressed in the heart and seems to be involved in cardiac fatty acid uptake. Therefore, we investigated whether a variation in the 5'-untranslated region of the FATP6 gene is associated with features of the metabolic syndrome and signs of myocardial alteration or heart failure. A total of 755 male participants from a Metabolic Intervention Cohort Kiel were genotyped for the FATP6-7T > A polymorphism (rs2526246) and phenotyped for features of the metabolic syndrome. Participants underwent a glucose tolerance test and the postprandial assessment of metabolic variables after a standardised mixed meal. Left ventricular heart function was evaluated in fifty-four participants. Fasting (P=0.01) and postprandial (P=0.02) TAG concentrations were significantly lower in AA homozygotes when compared with wild-type carriers. Homozygosity of allele A was associated with significantly lower postprandial insulin concentrations after a glucose load and significantly lower systolic (P=0-01) and diastolic (P=0.01) blood pressure values compared with wild-type carriers. Accordingly, left ventricular heart mass was significantly lower in twenty-seven AA homozygotes in comparison with twenty-seven IT homozygotes, matched for BMI (P=0.04). In conclusion, the effects of the FATP6 polymorphism on TAG are mediated by affluent dietary fat, The FATP6-7T > A polymorphism may protect from traits of the metabolic syndrome and CVD.

Document Type: Article
Additional Information: Fed Res Inst Nutr & Food, Dept Microbiol & Biotechnol, Max Rubner Inst, D-24103 Kiel, Germany. Fed Res Inst Nutr & Food, Dept Physiol & Biochem Nutr, Max Rubner Inst, D-24103 Kiel, Germany. Univ Hosp Schleswig Holstein UKSH, Dept Med 1, Clin Gen Internal Med, D-24105 Kiel, Germany. Fed Res Inst Nutr & Food, Dept Physiol & Biochem Nutr, Max Rubner Inst, D-76131 Karlsruhe, Germany. Clin Res Ctr Kiel, D-24118 Kiel, Germany. Univ Hosp Schleswig Holstein UKSH, Dept Cardiol, D-24105 Kiel, Germany. Auinger, A (reprint author), Fed Res Inst Nutr & Food, Dept Microbiol & Biotechnol, Max Rubner Inst, Hermann Weigmann Str 1, D-24103 Kiel, Germany. annegret.auinger@mri.bund.de
Keywords: Metabolic syndrome Cardiac hypertrophy Genetic variant Fatty acid transport protein lipoprotein-lipase glucose-metabolism gene-expression insulin sensitivity skeletal-muscle cardiomyopathy triglycerides deficiency resistance failure
Research affiliation: Kiel University > Faculty of Medicine > Institute of Clinical Molecular Biology
OceanRep > The Future Ocean - Cluster of Excellence
ISSN: 0007-1145
Projects: Future Ocean
Date Deposited: 14 May 2014 10:24
Last Modified: 14 May 2014 10:24
URI: http://eprints.uni-kiel.de/id/eprint/23799

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