Large scale biotechnological production of the antileukemic marine natural product sorbicillactone A

Bringmann, G., Gulder, T.A.M., Lang, Gerhard, Schmitt, S., Stöhr, Rüdiger, Wiese, Jutta, Nagel, Kerstin and Imhoff, Johannes F. (2007) Large scale biotechnological production of the antileukemic marine natural product sorbicillactone A Marine Drugs, 5 . pp. 23-30. DOI 10.3390/md502023.

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Abstract

In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have developed an efficient process for its biotechnological production and isolation on a large scale supplying sufficient material for the ongoing preclinical investigations and structure-activity relationship (SAR) studies.

Document Type: Article
Additional Information: WOS:000247557300002
Keywords: Biotechnology; sorbicillactone A; anti-leukemic activity; large-scale production; BIOTECmarin
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > GEOMAR > Applied R&D > Centre for Marine Substances (KiWiZ)
Refereed: Yes
DOI etc.: 10.3390/md502023
ISSN: 1660-3397
Projects: KIWIZ, BIOTECmarin, Future Ocean
Date Deposited: 03 Dec 2008 16:51
Last Modified: 02 Mar 2018 13:07
URI: http://eprints.uni-kiel.de/id/eprint/2296

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