Immune-Related Functions of the Hivep Gene Family in East African Cichlid Fishes

Diepeveen, E. T., Roth, Olivia and Salzburger, W. (2013) Immune-Related Functions of the Hivep Gene Family in East African Cichlid Fishes G3: Genes, Genomes, Genetics Mission , 3 (12). pp. 2205-2217. DOI 10.1534/g3.113.008839.

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Immune-related genes are often characterized by adaptive protein evolution. Selection on immune genes can be particularly strong when hosts encounter novel parasites, for instance, after the colonization of a new habitat or upon the exploitation of vacant ecological niches in an adaptive radiation. We examined a set of new candidate immune genes in East African cichlid fishes. More specifically, we studied the signatures of selection in five paralogs of the human immunodeficiency virus type I enhancer-binding protein (Hivep) gene family, tested their involvement in the immune defense, and related our results to explosive speciation and adaptive radiation events in cichlids. We found signatures of long-term positive selection in four Hivep paralogs and lineage-specific positive selection in Hivep3b in two radiating cichlid lineages. Exposure of the cichlid Astatotilapia burtoni to a vaccination with Vibrio anguillarum bacteria resulted in a positive correlation between immune response parameters and expression levels of three Hivep loci. This work provides the first evidence for a role of Hivep paralogs in teleost immune defense and links the signatures of positive selection to host-pathogen interactions within an adaptive radiation.

Document Type: Article
Additional Information: WOS:000328334500011
Keywords: adaptive radiation, immune response, molecular evolution, positive selection
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-EV Evolutionary Ecology of Marine Fishes
Refereed: Yes
DOI etc.: 10.1534/g3.113.008839
ISSN: 2160-1836
Date Deposited: 13 Dec 2013 12:27
Last Modified: 06 Oct 2017 08:11

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