Calcarides A–E, Antibacterial Macrocyclic and Linear Polyesters from a Calcarisporium Strain

Silber, Johanna, Ohlendorf, Birgit, Labes, Antje, Erhard, Arlette and Imhoff, Johannes F. (2013) Calcarides A–E, Antibacterial Macrocyclic and Linear Polyesters from a Calcarisporium Strain Marine Drugs, 11 (9). pp. 3309-3323. DOI 10.3390/md11093309.

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Abstract

Bioactive compounds were detected in crude extracts of the fungus, Calcarisporium sp. KF525, which was isolated from German Wadden Sea water samples. Purification of the metabolites from the extracts yielded the five known polyesters, 15G256α, α-2, β, β-2 and π (1–5), and five new derivatives thereof, named calcarides A–E (6–10). The chemical structures of the isolated compounds were elucidated on the basis of one- and two-dimensional NMR spectroscopy supported by UV and HRESIMS data. The compounds exhibited inhibitory activities against Staphylococcus epidermidis, Xanthomonas campestris and Propionibacterium acnes. As the antibacterial activities were highly specific with regard to compound and test strain, a tight structure-activity relationship is assumed.

Document Type: Article
Additional Information: WOS:000328621900013
Keywords: fungal natural products; Calcarisporium sp.; calcarides A–E; 15G256 components; macrocyclic and linear polyesters; antibacterial activities; antibiotic; marine natural products
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > GEOMAR > Applied R&D > Centre for Marine Substances (KiWiZ)
Refereed: Yes
DOI etc.: 10.3390/md11093309
ISSN: 1660-3397
Projects: Marine Fungi, Future Ocean
Date Deposited: 19 Sep 2013 09:30
Last Modified: 02 Mar 2018 12:53
URI: http://eprints.uni-kiel.de/id/eprint/21998

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