Helicusin E, Isochromophilone X and Isochromophilone XI: New Chloroazaphilones Produced by the Fungus Bartalinia robillardoides Strain LF550

Jansen, Nils, Ohlendorf, Birgit, Erhard, Arlette, Bruhn, Torsten, Bringmann, Gerhard and Imhoff, Johannes F. (2013) Helicusin E, Isochromophilone X and Isochromophilone XI: New Chloroazaphilones Produced by the Fungus Bartalinia robillardoides Strain LF550 Marine Drugs, 11 (3). pp. 800-816. DOI 10.3390/md11030800.

[img]
Preview
Text
marinedrugs-11-00800.pdf - Published Version
Available under License Creative Commons Attribution.

Download (588Kb) | Preview
[img]
Preview
Text
marinedrugs-11-00800-s001.pdf - Supplemental Material
Available under License Creative Commons Attribution.

Download (2039Kb) | Preview

Supplementary data:

Abstract

Microbial studies of the Mediterranean sponge Tethya aurantium led to the isolation of the fungus Bartalinia robillardoides strain LF550. The strain produced a number of secondary metabolites belonging to the chloroazaphilones. This is the first report on the isolation of chloroazaphilones of a fungal strain belonging to the genus Bartalinia. Besides some known compounds (helicusin A (1) and deacetylsclerotiorin (2)), three new chloroazaphilones (helicusin E (3); isochromophilone X (4) and isochromophilone XI (5)) and one new pentaketide (bartanolide (6)) were isolated. The structure elucidations were based on spectroscopic analyses. All isolated compounds revealed different biological activity spectra against a test panel of four bacteria: three fungi; two tumor cell lines and two enzymes.

Document Type: Article
Additional Information: WOS:000316607800014
Keywords: marine natural product; azaphilone; pentaketide; Bartalinia robillardoides; Tethya aurantium; ZETA VALENCE QUALITY; ENDOPHYTIC FUNGUS; ABSOLUTE-CONFIGURATION; PERTURBATION-THEORY; PENICILLIUM SP; BASIS-SETS; A-D; AZAPHILONES; DERIVATIVES
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > GEOMAR > Applied R&D > Centre for Marine Substances (KiWiZ)
Refereed: Yes
DOI etc.: 10.3390/md11030800
ISSN: 1660-3397
Projects: KIWIZ, EFRE, Future Ocean
Date Deposited: 23 Apr 2013 12:47
Last Modified: 02 Mar 2018 12:55
URI: http://eprints.uni-kiel.de/id/eprint/21140

Actions (login required)

View Item View Item

Document Downloads

More statistics for this item...