Unusual Regulation of a STAT Protein by an SLC6 Family Transporter in C. elegans Epidermal Innate Immunity

Dierking, K., Polanowska, J., Omi, S., Engelmann, I., Gut, M., Lembo, F., Ewbank, J. J. and Pujol, N. (2011) Unusual Regulation of a STAT Protein by an SLC6 Family Transporter in C. elegans Epidermal Innate Immunity Cell Host & Microbe, 9 (5). pp. 425-435. DOI 10.1016/j.chom.2011.04.011.

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Abstract

The cuticle and epidermis of Caenorhabditis elegans provide the first line of defense against invading pathogens. Upon invasion by the fungal pathogen Drechmeria coniospora, C. elegans responds by upregulating the expression of antimicrobial peptides (AMPs) in the epidermis via activation of at least two pathways, a neuroendocrine TGF-beta pathway and a p38 MAPK pathway. Here, we identify the sodium-neurotransmitter symporter SNF-12, a member of the solute carrier family (SLC6), as being essential for both these immune signaling pathways. We also identify the STAT transcription factor-like protein STA-2 as a direct physical interactor of SNF-12 and show that the two proteins function together to regulate AMP gene expression in the epidermis. Both SNF-12 and STA-2 act cell autonomously and specifically in the epidermis to govern the transcriptional response to fungal infection. These findings reveal an unorthodox mode of regulation for a STAT factor and highlight the molecular plasticity of innate immune signaling.

Document Type: Article
Keywords: caenorhabditis-elegans genome-wide mediated endocytosis fungal pathogens gene-expression domain protein infection responses kinase activation
Research affiliation: OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
DOI etc.: 10.1016/j.chom.2011.04.011
ISSN: 1931-3128
Projects: Future Ocean
Date Deposited: 01 Nov 2012 04:57
Last Modified: 07 Mar 2017 11:36
URI: http://eprints.uni-kiel.de/id/eprint/17054

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