Asymmetric Synthesis and Biological Activity of nor-alpha-Tocopherol, a New Vitamin E Analogue

Chapelat, J., Hengartner, U., Chougnet, A., Liu, K. G., Huebbe, P., Rimbach, G. and Woggon, W. D. (2011) Asymmetric Synthesis and Biological Activity of nor-alpha-Tocopherol, a New Vitamin E Analogue Chembiochem, 12 (1). pp. 118-124. DOI 10.1002/cbic.201000511.

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Abstract

The vitamin E analogues (2R,4'R, 8'R)-nor-alpha-tocopherol (94 de) and (2RS,4'R,8'R)-nor-alpha-tocopherol have been synthesized from (all R)-hexahydrofarnesol and phytol, respectively. According to in vitro experiments with murine macrophages nor-alpha-tocopherol is an anti-inflammatory compound more potent than alpha-tocopherol.

Document Type: Article
Keywords: inflammation nor-tocopherol tocopherol vitamins antioxidant activity gene-expression profile design derivatives principles
Research affiliation: Kiel University
Refereed: Yes
DOI etc.: 10.1002/cbic.201000511
ISSN: 1439-4227
Date Deposited: 01 Nov 2012 04:56
Last Modified: 23 Jan 2013 10:00
URI: http://eprints.uni-kiel.de/id/eprint/16979

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