Maternal Epigenetic Pathways Control Parental Contributions to Arabidopsis Early Embryogenesis

Autran, D., Baroux, C., Raissig, M. T., Lenormand, T., Wittig, M., Grob, S., Steimer, A., Barann, M., Klostermeier, U. C., Leblanc, O., Vielle-Calzada, J. P., Rosenstiel, P., Grimanelli, D. and Grossniklaus, U. (2011) Maternal Epigenetic Pathways Control Parental Contributions to Arabidopsis Early Embryogenesis Cell, 145 (5). pp. 707-719. DOI 10.1016/j.cell.2011.04.014.

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Abstract

Defining the contributions and interactions of paternal and maternal genomes during embryo development is critical to understand the fundamental processes involved in hybrid vigor, hybrid sterility, and reproductive isolation. To determine the parental contributions and their regulation during Arabidopsis embryogenesis, we combined deep-sequencing-based RNA profiling and genetic analyses. At the 2-4 cell stage there is a strong, genome-wide dominance of maternal transcripts, although transcripts are contributed by both parental genomes. At the globular stage the relative paternal contribution is higher, largely due to a gradual activation of the paternal genome. We identified two antagonistic maternal pathways that control these parental contributions. Paternal alleles are initially downregulated by the chromatin siRNA pathway, linked to DNA and histone methylation, whereas transcriptional activation requires maternal activity of the histone chaperone complex CAF1. Our results define maternal epigenetic pathways controlling the parental contributions in plant embryos, which are distinct from those regulating genomic imprinting.

Document Type: Article
Keywords: to-zygotic transition seed development small-rna endosperm development dna methylation paternal genome chromatin embryo maintenance expression
Research affiliation: Kiel University
Refereed: Yes
DOI etc.: 10.1016/j.cell.2011.04.014
ISSN: 0092-8674
Date Deposited: 01 Nov 2012 04:58
Last Modified: 23 Jan 2013 10:04
URI: http://eprints.uni-kiel.de/id/eprint/16705

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