Rapid and adaptive evolution of MHC genes under parasite selection in experimental vertebrate populations

Eizaguirre, Christophe, Lenz, T. L., Kalbe, M. and Milinski, M. (2012) Rapid and adaptive evolution of MHC genes under parasite selection in experimental vertebrate populations Nature Communications, 3 . p. 621. DOI 10.1038/ncomms1632.

[img]
Preview
Text
ncomms1632.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial Share Alike.

Download (486Kb) | Preview

Supplementary data:

Abstract

The genes of the major histocompatibility complex are the most polymorphic genes in vertebrates, with more than 1,000 alleles described in human populations. How this polymorphism is maintained, however, remains an evolutionary puzzle. Major histocompatibility complex genes have a crucial function in the adaptive immune system by presenting parasite-derived antigens to T lymphocytes. Because of this function, varying parasite-mediated selection has been proposed as a major evolutionary force for maintaining major histocompatibility complex polymorphism. A necessary prerequisite of such a balancing selection process is rapid major histocompatibility complex allele frequency shifts resulting from emerging selection by a specific parasite. Here we show in six experimental populations of sticklebacks, each exposed to one of two different parasites, that only those major histocompatibility complex alleles providing resistance to the respective specific parasite increased in frequency in the next host generation. This result demonstrates experimentally that varying parasite selection causes rapid adaptive evolutionary changes, thus facilitating the maintenance of major histocompatibility complex polymorphism.

Document Type: Article
Keywords: Evolutionary Ecology of Marine Fishes; MAJOR HISTOCOMPATIBILITY COMPLEX; FREQUENCY-DEPENDENT SELECTION; EXPERIMENTAL COEVOLUTION; HETEROZYGOTE ADVANTAGE; SEXUAL SELECTION; MATE CHOICE; HOST; POLYMORPHISM; DIVERSITY; ADAPTATION
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-EV Evolutionary Ecology of Marine Fishes
Refereed: Yes
DOI etc.: 10.1038/ncomms1632
ISSN: 2041-1723
Date Deposited: 02 Dec 2011 14:35
Last Modified: 13 Jan 2014 12:32
URI: http://eprints.uni-kiel.de/id/eprint/12716

Actions (login required)

View Item View Item

Document Downloads

More statistics for this item...