Abenquines A–D: aminoquinone derivatives produced by Streptomyces sp. strain DB634

Schulz, Dirk, Beese, Pascal, Ohlendorf, Birgit, Erhard, Arlette, Zinecker, Heidi, Dorador, Cristina and Imhoff, Johannes F. (2011) Abenquines A–D: aminoquinone derivatives produced by Streptomyces sp. strain DB634 The Journal of Antibiotics, 64 . pp. 763-768. DOI 10.1038/ja.2011.87.

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Supplementary data:


New bioactive secondary metabolites, called abenquines, were found in the fermentation broth of Streptomyces sp. strain DB634, which was isolated from the soils of the Chilean highland of the Atacama Desert. They are composed of an amino acid linked to an N-acetyl-aminobenzoquinone. Isolation of the abenquines (1-4), their structure elucidation by NMR analysis and MS, as well as the kinetics of their production are presented. The abenquines show inhibitory activity against bacteria, dermatophytic fungi and phosphodiesterase type 4b. The amino acid attached to the quinone is relevant to the enzyme inhibitory activity.

Document Type: Article
Keywords: Microbiology; aminoquinones; phosphodiesterase type 4b; Streptomyces
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > GEOMAR > Applied R&D > Centre for Marine Substances (KiWiZ)
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
DOI etc.: 10.1038/ja.2011.87
ISSN: 0021-8820
Projects: KIWIZ, Future Ocean
Date Deposited: 01 Dec 2011 08:18
Last Modified: 25 May 2016 09:40
URI: http://eprints.uni-kiel.de/id/eprint/12673

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