Eutypoids B−E Produced by aPenicilliumsp. Strain from the North Sea

Schulz, Dirk, Ohlendorf, Birgit, Zinecker, Heidi, Schmaljohann, Rolf and Imhoff, Johannes F. (2011) Eutypoids B−E Produced by aPenicilliumsp. Strain from the North Sea Journal of Natural Products, 74 (1). pp. 99-101. DOI 10.1021/np100633k.

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Crude extracts of the Penicillium sp. strain KF620 isolated from the North Sea showed antimicrobial activities against Xanthomonas campestris and Candida glabrata. Purification of the extracts led to the isolation of the new aromatic butenolides eutypoids B (1), C (2), D (3), and E (4). Their structures were elucidated by NMR spectroscopy and supported by HRESIMS and UV data. The antibacterial activity of the crude extracts was due to the presence of the known diketopiperazine fellutanine (cyclo(Trp-Trp)). The eutypoids were neither cytotoxic nor antibacterial, but inhibited the activity of glycogen synthase kinase-3β

Document Type: Article
Keywords: Microbiology
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
OceanRep > The Future Ocean - Cluster of Excellence
Refereed: Yes
DOI etc.: 10.1021/np100633k
ISSN: 0163-3864
Projects: Future Ocean
Date Deposited: 13 May 2011 12:02
Last Modified: 06 Jul 2012 15:06

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