Levantilides A and B, 20-Membered Macrolides from a Micromonospora Strain Isolated from the Mediterranean Deep Sea Sediment

Gärtner, Andrea, Ohlendorf, Birgit, Schulz, Dirk, Zinecker, Heidi, Wiese, Jutta and Imhoff, Johannes F. (2011) Levantilides A and B, 20-Membered Macrolides from a Micromonospora Strain Isolated from the Mediterranean Deep Sea Sediment Marine Drugs, 9 (1). pp. 98-108. DOI 10.3390/md9010098.

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Abstract

Two new 20-membered macrolides, levantilide A and B, were isolated from the Micromonospora strain M71-A77. Strain M71-A77 was recovered from an Eastern Mediterranean deep-sea sediment sample and revealed to produce the levantilides under in situ salinity of 38.6‰. The chemical structures of the levantilides were elucidated on the basis of different one- and two- dimensional NMR experiments. Levantilide A exhibits a moderate antiproliferative activity against several tumor cell lines.

Document Type: Article
Additional Information: WOS:000288892000007
Keywords: Microbiology; macrolide; Micromonospora; deep sea; natural product; marine; DINOFLAGELLATE AMPHIDINIUM SP; ACTINOMYCETE DIVERSITY; BIOACTIVE METABOLITES; MARINE; TAXONOMY; DISCOVERY
Research affiliation: OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
Refereed: Yes
DOI etc.: 10.3390/md9010098
ISSN: 1660-3397
Projects: Future Ocean
Date Deposited: 13 May 2011 11:33
Last Modified: 02 Mar 2018 13:03
URI: http://eprints.uni-kiel.de/id/eprint/11846

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